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Title: Flow sensing of single cell by graphene transistor in a microfluidic channel
Authors: Ang, P.K. 
Li, A. 
Jaiswal, M. 
Wang, Y. 
Hou, H.W.
Thong, J.T.L. 
Lim, C.T. 
Loh, K.P. 
Keywords: cell surface charge density
field-effect transistor
infectious disease
single cell detection
Issue Date: 14-Dec-2011
Citation: Ang, P.K., Li, A., Jaiswal, M., Wang, Y., Hou, H.W., Thong, J.T.L., Lim, C.T., Loh, K.P. (2011-12-14). Flow sensing of single cell by graphene transistor in a microfluidic channel. Nano Letters 11 (12) : 5240-5246. ScholarBank@NUS Repository.
Abstract: The electronic properties of graphene are strongly influenced by electrostatic forces arising from long-range charge scatterers and by changes in the local dielectric environment. This makes graphene extremely sensitive to the surface charge density of cells interfacing with it. Here, we developed a graphene transistor array integrated with microfluidic flow cytometry for the "flow-catch-release" sensing of malaria-infected red blood cells at the single-cell level. Malaria-infected red blood cells induce highly sensitive capacitively coupled changes in the conductivity of graphene. Together with the characteristic conductance dwell times, specific microscopic information about the disease state can be obtained. © 2011 American Chemical Society.
Source Title: Nano Letters
ISSN: 15306984
DOI: 10.1021/nl202579k
Appears in Collections:Staff Publications

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