Please use this identifier to cite or link to this item:
|Title:||Alterations in retinal microvascular geometry in young type 1 diabetes||Authors:||Sasongko, M.B.
|Issue Date:||2010||Citation:||Sasongko, M.B., Wang, J.J., Donaghue, K.C., Cheung, N., Benitez-Aguirre, P., Jenkins, A., Hsu, W., Lee, M.-L., Wong, T.Y. (2010). Alterations in retinal microvascular geometry in young type 1 diabetes. Diabetes Care 33 (6) : 1331-1336. ScholarBank@NUS Repository. https://doi.org/10.2337/dc10-0055||Abstract:||OBJECTIVE - To describe retinal microvascular geometric parameters in young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS - Patients with type 1 diabetes (aged 12-20 years) had clinical assessments and retinal photography following standardized protocol at a tertiary-care hospital in Sydney. Retinal microvascular geometry, including arteriolar and venular tortuosity, branching angles, optimality deviation, and length-to-diameter ratio (LDR), were measured from digitized photographs. Associations of these geometric characteristics with diabetes duration, A1C level, systolic blood pressure (SBP), and other risk factors were assessed. RESULTS - Of 1,159 patients enrolled, 944 (81.4%) had gradable photographs and 170 (14.7%) had retinopathy. Older age was associated with decreased arteriolar (P = 0.024) and venular (P = 0.002) tortuosity, and female subjects had larger arteriolar branching angle than male subjects (P = 0.03). After adjusting for age and sex, longer diabetes duration was associated with larger arteriolar branching angle (P ≤ 0.001) and increased arteriolar optimality deviation (P = 0.018), higher A1C was associated with increased arteriolar tortuosity (>8.5 vs. ≤8.5%, P = 0.008), higher SBP was associated with decreased arteriolar LDR (P = 0.002), and higher total cholesterol levels were associated with increased arteriolar LDR (P = 0.044) and decreased venular optimality deviation (P = 0.044). These associations remained after controlling for A1C, retinal vessel caliber, and retinopathy status and were seen in subjects without retinopathy. CONCLUSIONS - Key diabetes-related factors affect retinal microvascular geometry in young type 1 diabetes, even in those without evidence of retinopathy. These early retinal alterations may be markers of diabetes microvascular complications. © 2010 by the American Diabetes Association.||Source Title:||Diabetes Care||URI:||http://scholarbank.nus.edu.sg/handle/10635/43086||ISSN:||01495992||DOI:||10.2337/dc10-0055|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 25, 2019
WEB OF SCIENCETM
checked on Jun 25, 2019
checked on Jun 22, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.