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Title: Alterations in retinal microvascular geometry in young type 1 diabetes
Authors: Sasongko, M.B.
Wang, J.J.
Donaghue, K.C.
Cheung, N.
Benitez-Aguirre, P.
Jenkins, A.
Hsu, W. 
Lee, M.-L. 
Wong, T.Y. 
Issue Date: 2010
Citation: Sasongko, M.B., Wang, J.J., Donaghue, K.C., Cheung, N., Benitez-Aguirre, P., Jenkins, A., Hsu, W., Lee, M.-L., Wong, T.Y. (2010). Alterations in retinal microvascular geometry in young type 1 diabetes. Diabetes Care 33 (6) : 1331-1336. ScholarBank@NUS Repository.
Abstract: OBJECTIVE - To describe retinal microvascular geometric parameters in young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS - Patients with type 1 diabetes (aged 12-20 years) had clinical assessments and retinal photography following standardized protocol at a tertiary-care hospital in Sydney. Retinal microvascular geometry, including arteriolar and venular tortuosity, branching angles, optimality deviation, and length-to-diameter ratio (LDR), were measured from digitized photographs. Associations of these geometric characteristics with diabetes duration, A1C level, systolic blood pressure (SBP), and other risk factors were assessed. RESULTS - Of 1,159 patients enrolled, 944 (81.4%) had gradable photographs and 170 (14.7%) had retinopathy. Older age was associated with decreased arteriolar (P = 0.024) and venular (P = 0.002) tortuosity, and female subjects had larger arteriolar branching angle than male subjects (P = 0.03). After adjusting for age and sex, longer diabetes duration was associated with larger arteriolar branching angle (P ≤ 0.001) and increased arteriolar optimality deviation (P = 0.018), higher A1C was associated with increased arteriolar tortuosity (>8.5 vs. ≤8.5%, P = 0.008), higher SBP was associated with decreased arteriolar LDR (P = 0.002), and higher total cholesterol levels were associated with increased arteriolar LDR (P = 0.044) and decreased venular optimality deviation (P = 0.044). These associations remained after controlling for A1C, retinal vessel caliber, and retinopathy status and were seen in subjects without retinopathy. CONCLUSIONS - Key diabetes-related factors affect retinal microvascular geometry in young type 1 diabetes, even in those without evidence of retinopathy. These early retinal alterations may be markers of diabetes microvascular complications. © 2010 by the American Diabetes Association.
Source Title: Diabetes Care
ISSN: 01495992
DOI: 10.2337/dc10-0055
Appears in Collections:Staff Publications

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