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https://scholarbank.nus.edu.sg/handle/10635/34938
Title: | Cholesterol biosynthesis pathway modulators and uses thereof | Authors: | JEYASEELAN, KANDIAH ARMUGAM, ARUNMOZHIARASI CHAI, SIAW CHING RAMKISHEN, PRABHAKARAN NAIR GOPALAKRISHNAKONE, PONNAMPALAM TAN, KWON HUAT BENNY |
Issue Date: | 5-Oct-2006 | Citation: | JEYASEELAN, KANDIAH, ARMUGAM, ARUNMOZHIARASI, CHAI, SIAW CHING, RAMKISHEN, PRABHAKARAN NAIR, GOPALAKRISHNAKONE, PONNAMPALAM, TAN, KWON HUAT BENNY (2006-10-05). Cholesterol biosynthesis pathway modulators and uses thereof. ScholarBank@NUS Repository. | Abstract: | An isolated peptide comprising the amino acid sequence of SEQ ID NO: 2, or a variant, derivative and/or fragment thereof having the function of HMGCoA reductase inhibitor, phosphomevalonate inhibitor, reducing the accumulation of cholesterol in the cholesterol biosynthesis pathway and/or reducing the level of serum cholesterol. Also disclosed is a pharmaceutical composition comprising the peptide having sequence SEQ ID NO:2 or a variant, derivative and/or fragment thereof. Also disclosed is a method for treatment or prophylaxis of disorders characterised by the accumulation of cholesterol, its by-products and/or related lipid derived products, comprising administering to a subject in need at least one peptide comprising the amino acid sequence of SEQ ID NO: 2, or a variant, derivative and/or fragment thereof. | URI: | http://scholarbank.nus.edu.sg/handle/10635/34938 |
Appears in Collections: | Staff Publications |
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