Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/34938
Title: Cholesterol biosynthesis pathway modulators and uses thereof
Authors: JEYASEELAN, KANDIAH 
ARMUGAM, ARUNMOZHIARASI 
CHAI, SIAW CHING 
RAMKISHEN, PRABHAKARAN NAIR 
GOPALAKRISHNAKONE, PONNAMPALAM 
TAN, KWON HUAT BENNY 
Issue Date: 5-Oct-2006
Source: JEYASEELAN, KANDIAH,ARMUGAM, ARUNMOZHIARASI,CHAI, SIAW CHING,RAMKISHEN, PRABHAKARAN NAIR,GOPALAKRISHNAKONE, PONNAMPALAM,TAN, KWON HUAT BENNY (2006-10-05). Cholesterol biosynthesis pathway modulators and uses thereof. ScholarBank@NUS Repository.
Abstract: An isolated peptide comprising the amino acid sequence of SEQ ID NO: 2, or a variant, derivative and/or fragment thereof having the function of HMGCoA reductase inhibitor, phosphomevalonate inhibitor, reducing the accumulation of cholesterol in the cholesterol biosynthesis pathway and/or reducing the level of serum cholesterol. Also disclosed is a pharmaceutical composition comprising the peptide having sequence SEQ ID NO:2 or a variant, derivative and/or fragment thereof. Also disclosed is a method for treatment or prophylaxis of disorders characterised by the accumulation of cholesterol, its by-products and/or related lipid derived products, comprising administering to a subject in need at least one peptide comprising the amino acid sequence of SEQ ID NO: 2, or a variant, derivative and/or fragment thereof.
URI: http://scholarbank.nus.edu.sg/handle/10635/34938
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