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Title: Infiltrating lymphocytes in undifferentiated nasopharyngeal cancer lack metallothionein expression
Authors: Jayasurya, A. 
Bay, B.-H. 
Yap, W.-M.
Tan, N.-G.
Keywords: Electron microscopy
Metallothionein protein expression
Nasopharyngeal carcinoma
Issue Date: 2000
Citation: Jayasurya, A., Bay, B.-H., Yap, W.-M., Tan, N.-G. (2000). Infiltrating lymphocytes in undifferentiated nasopharyngeal cancer lack metallothionein expression. Cancer Letters 155 (1) : 99-104. ScholarBank@NUS Repository.
Abstract: Metallothionein (MT) is a metal-binding protein with functional roles in cell growth, repair and differentiation. MT is reported to be differentially expressed in lymphocytes of malignant gastrointestinal lesions. The level of MT protein was examined by immunohistochemical analysis at light microscopic and ultrastructural level in infiltrating lymphocytes from 20 cases of undifferentiated nasopharyngeal carcinoma (NPC). MT expression was found to be absent in the infiltrating lymphocytes of NPC and in reactive lymphocytes of lymphoid hyperplasia in nasopharyngeal tissues. Ultrastructural examination confirmed the absence of MT immunoreactivity in the lymphoid infiltrate of NPC. On the other hand, malignant lymphoblasts of diffuse large cell lymphoma, showed MT-immunopositivity by immunoelectron microscopy. This study demonstrates a lack of MT expression in the lymphoid stroma of undifferentiated NPC, a further characteristic of its non-neoplastic nature. (C) 2000 Elsevier Science Ireland Ltd.
Source Title: Cancer Letters
ISSN: 03043835
DOI: 10.1016/S0304-3835(00)00414-6
Appears in Collections:Staff Publications

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