Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1600-0773.1989.tb00610.x
Title: Depression of the hepatic cytochrome P-450 monooxygenase system by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Authors: Shahi, G.S. 
Moochhala, S.M. 
Das, N.P. 
Issue Date: Jan-1989
Citation: Shahi, G.S., Moochhala, S.M., Das, N.P. (1989-01). Depression of the hepatic cytochrome P-450 monooxygenase system by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Pharmacology and Toxicology 64 (1) : 107-110. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1600-0773.1989.tb00610.x
Abstract: The effects of the neurotoxic compound, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the hepatic cytochrome P-450 monooxygenase system were assessed using C57 BL/6J mice. Treatment with MPTP caused a marked depression of hepatic cytochrome P-450 content, ethoxyresorufin O-dealkylase and NADPH cytochrome C reductase activities. This effect was maximal 3 to 6 hours after treatment and was dependent on the dose of MPTP administered. Depression of spectrophotometrically measured cytochrome P-450 content was associated with increase in cytochrome P-420 content and lipid peroxidation. In vitro studies showed the formation of a metabolic-intermediate complex with cytochrome P-450 which may partially explain the depression of cytochrome P-450 content and activity by MPTP.
Source Title: Pharmacology and Toxicology
URI: http://scholarbank.nus.edu.sg/handle/10635/32276
ISSN: 09019928
DOI: 10.1111/j.1600-0773.1989.tb00610.x
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