Please use this identifier to cite or link to this item:
https://doi.org/10.1111/j.1600-0773.1989.tb00610.x
DC Field | Value | |
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dc.title | Depression of the hepatic cytochrome P-450 monooxygenase system by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) | |
dc.contributor.author | Shahi, G.S. | |
dc.contributor.author | Moochhala, S.M. | |
dc.contributor.author | Das, N.P. | |
dc.date.accessioned | 2012-04-02T07:55:11Z | |
dc.date.available | 2012-04-02T07:55:11Z | |
dc.date.issued | 1989-01 | |
dc.identifier.citation | Shahi, G.S., Moochhala, S.M., Das, N.P. (1989-01). Depression of the hepatic cytochrome P-450 monooxygenase system by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Pharmacology and Toxicology 64 (1) : 107-110. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1600-0773.1989.tb00610.x | |
dc.identifier.issn | 09019928 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/32276 | |
dc.description.abstract | The effects of the neurotoxic compound, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the hepatic cytochrome P-450 monooxygenase system were assessed using C57 BL/6J mice. Treatment with MPTP caused a marked depression of hepatic cytochrome P-450 content, ethoxyresorufin O-dealkylase and NADPH cytochrome C reductase activities. This effect was maximal 3 to 6 hours after treatment and was dependent on the dose of MPTP administered. Depression of spectrophotometrically measured cytochrome P-450 content was associated with increase in cytochrome P-420 content and lipid peroxidation. In vitro studies showed the formation of a metabolic-intermediate complex with cytochrome P-450 which may partially explain the depression of cytochrome P-450 content and activity by MPTP. | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | BIOCHEMISTRY | |
dc.contributor.department | PHARMACOLOGY | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.doi | 10.1111/j.1600-0773.1989.tb00610.x | |
dc.description.sourcetitle | Pharmacology and Toxicology | |
dc.description.volume | 64 | |
dc.description.issue | 1 | |
dc.description.page | 107-110 | |
dc.description.coden | PHTOE | |
dc.identifier.isiut | NOT_IN_WOS | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications |
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