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https://doi.org/10.1016/j.transproceed.2004.11.057
Title: | Xenotransplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed streptozotocin-induced diabetic rats | Authors: | Wang, D.Z. Khoo, A. Calne, R. Isaac, J.R. Lee, K.O. Salto-Tellez, M. Skinner, S. Elliot, R. Garkavenko, O. Escobar, L. |
Issue Date: | 2005 | Citation: | Wang, D.Z., Khoo, A., Calne, R., Isaac, J.R., Lee, K.O., Salto-Tellez, M., Skinner, S., Elliot, R., Garkavenko, O., Escobar, L. (2005). Xenotransplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed streptozotocin-induced diabetic rats. Transplantation Proceedings 37 (1) : 470-471. ScholarBank@NUS Repository. https://doi.org/10.1016/j.transproceed.2004.11.057 | Abstract: | The testis has been shown to be a privileged site for transplantation of allogenic islets in rodents, and the testicular cell aggregates are thought to confer this immunologic privilege. Recently, a group in Mexico reported transplantation of cocultured neonatal porcine islets and Sertoli cells resulting in insulin independence in nonimmunosuppressed type 1 diabetes patients. We have transplanted similar islets alone (naked islets) or cocultured islets with Sertoli cells (islet/Sertoli cells) into an omental site and other locations of nonimmunosuppressed, streptozotocin-induced diabetic male Sprague Dawley (SD) rats. Histologic examination showed viable neonatal porcine islets survived in xenografted rodents for at least 2 days, and some glucagon and inhibin stained cells appear to have survived for 4 days posttransplantation. However, histological examination did not demonstrate any difference in xenograft survival in the islets/Sertoli cells mixture compared to naked islets when transplanted into these nonimmunosuppressed diabetic rats. © 2005 by Elsevier Inc. All rights reserved. | Source Title: | Transplantation Proceedings | URI: | http://scholarbank.nus.edu.sg/handle/10635/30514 | ISSN: | 00411345 | DOI: | 10.1016/j.transproceed.2004.11.057 |
Appears in Collections: | Staff Publications |
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