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Title: Xenotransplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed streptozotocin-induced diabetic rats
Authors: Wang, D.Z.
Khoo, A. 
Calne, R. 
Isaac, J.R. 
Lee, K.O. 
Salto-Tellez, M. 
Skinner, S.
Elliot, R.
Garkavenko, O.
Escobar, L.
Issue Date: 2005
Citation: Wang, D.Z., Khoo, A., Calne, R., Isaac, J.R., Lee, K.O., Salto-Tellez, M., Skinner, S., Elliot, R., Garkavenko, O., Escobar, L. (2005). Xenotransplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed streptozotocin-induced diabetic rats. Transplantation Proceedings 37 (1) : 470-471. ScholarBank@NUS Repository.
Abstract: The testis has been shown to be a privileged site for transplantation of allogenic islets in rodents, and the testicular cell aggregates are thought to confer this immunologic privilege. Recently, a group in Mexico reported transplantation of cocultured neonatal porcine islets and Sertoli cells resulting in insulin independence in nonimmunosuppressed type 1 diabetes patients. We have transplanted similar islets alone (naked islets) or cocultured islets with Sertoli cells (islet/Sertoli cells) into an omental site and other locations of nonimmunosuppressed, streptozotocin-induced diabetic male Sprague Dawley (SD) rats. Histologic examination showed viable neonatal porcine islets survived in xenografted rodents for at least 2 days, and some glucagon and inhibin stained cells appear to have survived for 4 days posttransplantation. However, histological examination did not demonstrate any difference in xenograft survival in the islets/Sertoli cells mixture compared to naked islets when transplanted into these nonimmunosuppressed diabetic rats. © 2005 by Elsevier Inc. All rights reserved.
Source Title: Transplantation Proceedings
ISSN: 00411345
DOI: 10.1016/j.transproceed.2004.11.057
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