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Title: Programmed cell death in fission yeast Schizosaccharomyces pombe
Authors: Low, C.P. 
Yang, H. 
Keywords: Apoptosis
Cell cycle checkpoint
Chronological aging
Fission yeast
Programmed cell death
Protein kinase C
Reactive oxygen species
Replication defect
Replicative aging
Schizosaccharomyces pombe
Issue Date: 2008
Citation: Low, C.P., Yang, H. (2008). Programmed cell death in fission yeast Schizosaccharomyces pombe. Biochimica et Biophysica Acta - Molecular Cell Research 1783 (7) : 1335-1349. ScholarBank@NUS Repository.
Abstract: Yeasts have proven to be invaluable, genetically tractable systems to study various fundamental biological processes including programmed cell death. Recent advances in the elucidation of the molecular pathways underlying apoptotic cell death in yeasts have revealed remarkable similarities to mammalian apoptosis at cellular, organelle and macromolecular levels, thus making a strong case for the relevance of yeast models of regulated cell death. Programmed cell death has been reported in fission yeast Schizosaccharomyces pombe, primarily in the contexts of perturbed intracellular lipid metabolism, defective DNA replication, improper mitotic entry, chronological and replicative aging. Here we review the current understanding of the programmed cell death in fission yeast, paying particular attention to lipid-induced cell death. We discuss our recent findings that fission yeast exhibits plasticity of apoptotic and non-apoptotic modes of cell death in response to different lipid stimuli and growth conditions, and that mitochondria, reactive oxygen species and novel cell death mediators including metacaspase Pca1, SpRad9 and Pck1 are involved in the lipotoxic cell death. We also present perspectives on how various aspects of the cell and molecular biology of this organism can be explored to shed light on the governing principles underlying lipid-mediated signaling and cell demise. © 2008 Elsevier B.V. All rights reserved.
Source Title: Biochimica et Biophysica Acta - Molecular Cell Research
ISSN: 01674889
DOI: 10.1016/j.bbamcr.2008.02.002
Appears in Collections:Staff Publications

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