Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbamcr.2008.02.002
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dc.titleProgrammed cell death in fission yeast Schizosaccharomyces pombe
dc.contributor.authorLow, C.P.
dc.contributor.authorYang, H.
dc.date.accessioned2011-11-29T05:59:11Z
dc.date.available2011-11-29T05:59:11Z
dc.date.issued2008
dc.identifier.citationLow, C.P., Yang, H. (2008). Programmed cell death in fission yeast Schizosaccharomyces pombe. Biochimica et Biophysica Acta - Molecular Cell Research 1783 (7) : 1335-1349. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbamcr.2008.02.002
dc.identifier.issn01674889
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28765
dc.description.abstractYeasts have proven to be invaluable, genetically tractable systems to study various fundamental biological processes including programmed cell death. Recent advances in the elucidation of the molecular pathways underlying apoptotic cell death in yeasts have revealed remarkable similarities to mammalian apoptosis at cellular, organelle and macromolecular levels, thus making a strong case for the relevance of yeast models of regulated cell death. Programmed cell death has been reported in fission yeast Schizosaccharomyces pombe, primarily in the contexts of perturbed intracellular lipid metabolism, defective DNA replication, improper mitotic entry, chronological and replicative aging. Here we review the current understanding of the programmed cell death in fission yeast, paying particular attention to lipid-induced cell death. We discuss our recent findings that fission yeast exhibits plasticity of apoptotic and non-apoptotic modes of cell death in response to different lipid stimuli and growth conditions, and that mitochondria, reactive oxygen species and novel cell death mediators including metacaspase Pca1, SpRad9 and Pck1 are involved in the lipotoxic cell death. We also present perspectives on how various aspects of the cell and molecular biology of this organism can be explored to shed light on the governing principles underlying lipid-mediated signaling and cell demise. © 2008 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbamcr.2008.02.002
dc.sourceScopus
dc.subjectApoptosis
dc.subjectBzz1
dc.subjectCell cycle checkpoint
dc.subjectCeramide
dc.subjectChronological aging
dc.subjectDiacylglycerol
dc.subjectFission yeast
dc.subjectLipoapoptosis
dc.subjectLipotoxicity
dc.subjectMetacaspase
dc.subjectMitochondria
dc.subjectPca1
dc.subjectPck1
dc.subjectProgrammed cell death
dc.subjectProtein kinase C
dc.subjectRad9
dc.subjectReactive oxygen species
dc.subjectReplication defect
dc.subjectReplicative aging
dc.subjectSchizosaccharomyces pombe
dc.subjectTriacylglycerol
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.bbamcr.2008.02.002
dc.description.sourcetitleBiochimica et Biophysica Acta - Molecular Cell Research
dc.description.volume1783
dc.description.issue7
dc.description.page1335-1349
dc.description.codenBAMRD
dc.identifier.isiut000257555300009
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