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https://scholarbank.nus.edu.sg/handle/10635/27681
| Title: | The role of BLNK, DOK-3 & DIP in BCR signaling | Authors: | TAN EN-LIN, JOY | Keywords: | BCR, B cell antigen receptor; BLNK, B cell linker protein; Dok-3, downstream of tyrosine kinase –3 DIP, Dok-interacting protein | Issue Date: | 10-Dec-2004 | Citation: | TAN EN-LIN, JOY (2004-12-10). The role of BLNK, DOK-3 & DIP in BCR signaling. ScholarBank@NUS Repository. | Abstract: | Engagement of the BCR leads to various cellular responses in B cells. Adaptor proteins were found to be responsible for co-ordinating activated upstream PTKs with downstream signaling events. In this study, we demonstrate the role of both a positive adaptor protein, BLNK and also that of a negative adaptor protein known as Dok-3 in B cell signaling. BLNK is necessary for NF-kappa B and PLCgamma 2 activation through BCR, but not necessary for activating MAPKs, Btk and Atk. On the other hand, Dok-3 acts in an inhibitory manner by localising to the lipid rafts with SHIP, only upon FcgammaRIIB (an inhibitory receptor) activation, and interacting with a novel apoptotic molecule termed DIP. | URI: | https://scholarbank.nus.edu.sg/handle/10635/27681 |
| Appears in Collections: | Ph.D Theses (Open) |
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| File | Description | Size | Format | Access Settings | Version | |
|---|---|---|---|---|---|---|
| Joy Tan En-Lin1.pdf | 3.84 MB | Adobe PDF | OPEN | None | View/Download | |
| XSLpaper.pdf | 284.63 kB | Adobe PDF | OPEN | None | View/Download |
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