Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/27681
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dc.titleThe role of BLNK, DOK-3 & DIP in BCR signaling
dc.contributor.authorTAN EN-LIN, JOY
dc.date.accessioned2011-10-12T18:01:10Z
dc.date.available2011-10-12T18:01:10Z
dc.date.issued2004-12-10
dc.identifier.citationTAN EN-LIN, JOY (2004-12-10). The role of BLNK, DOK-3 & DIP in BCR signaling. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/27681
dc.description.abstractEngagement of the BCR leads to various cellular responses in B cells. Adaptor proteins were found to be responsible for co-ordinating activated upstream PTKs with downstream signaling events. In this study, we demonstrate the role of both a positive adaptor protein, BLNK and also that of a negative adaptor protein known as Dok-3 in B cell signaling. BLNK is necessary for NF-kappa B and PLCgamma 2 activation through BCR, but not necessary for activating MAPKs, Btk and Atk. On the other hand, Dok-3 acts in an inhibitory manner by localising to the lipid rafts with SHIP, only upon FcgammaRIIB (an inhibitory receptor) activation, and interacting with a novel apoptotic molecule termed DIP.
dc.language.isoen
dc.subjectBCR, B cell antigen receptor; BLNK, B cell linker protein; Dok-3, downstream of tyrosine kinase –3 DIP, Dok-interacting protein
dc.typeThesis
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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