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Title: Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand
Authors: Chang, S.Y. 
Yong, T.F.
Liang, M.C. 
Soong, T.W. 
Yu, C.Y.
Pletnikova, O.
Troncoso, J.
Burgunder, J.-M. 
Keywords: aging
calcium channel
developmental switch
EF hand
mutually-exclusive exons
Issue Date: 2007
Citation: Chang, S.Y., Yong, T.F., Liang, M.C., Soong, T.W., Yu, C.Y., Pletnikova, O., Troncoso, J., Burgunder, J.-M. (2007). Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand. Neuroscience 145 (3) : 1026-1036. ScholarBank@NUS Repository.
Abstract: Cav2.1 Ca2+ channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its alternatively-spliced exons is 37, which forms part of the EF hand. The expression of exon 37a (EFa form), but not exon 37b (EFb form), confers the channel an activity-dependent enhancement of channel opening known as Ca2+-dependent facilitation (CDF). In this study, we analyzed the trend of EF hand splice variant distributions in mouse, rat and human brain tissues. We observed a developmental switch in rodents, as well as an age and gender bias in human brain tissues, suggestive of a possible role of these EF hand splice variants in neurophysiological specialization. A parallel study performed on rodent brains showed that the data drawn from human and rodent tissues may not necessarily correlate in the process of aging. © 2007 IBRO.
Source Title: Neuroscience
ISSN: 03064522
DOI: 10.1016/j.neuroscience.2006.12.054
Appears in Collections:Staff Publications

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