Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neuroscience.2006.12.054
Title: Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand
Authors: Chang, S.Y. 
Yong, T.F.
Liang, M.C. 
Soong, T.W. 
Yu, C.Y.
Pletnikova, O.
Troncoso, J.
Burgunder, J.-M. 
Keywords: aging
calcium channel
developmental switch
EF hand
mutually-exclusive exons
Issue Date: 2007
Citation: Chang, S.Y., Yong, T.F., Liang, M.C., Soong, T.W., Yu, C.Y., Pletnikova, O., Troncoso, J., Burgunder, J.-M. (2007). Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand. Neuroscience 145 (3) : 1026-1036. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuroscience.2006.12.054
Abstract: Cav2.1 Ca2+ channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its alternatively-spliced exons is 37, which forms part of the EF hand. The expression of exon 37a (EFa form), but not exon 37b (EFb form), confers the channel an activity-dependent enhancement of channel opening known as Ca2+-dependent facilitation (CDF). In this study, we analyzed the trend of EF hand splice variant distributions in mouse, rat and human brain tissues. We observed a developmental switch in rodents, as well as an age and gender bias in human brain tissues, suggestive of a possible role of these EF hand splice variants in neurophysiological specialization. A parallel study performed on rodent brains showed that the data drawn from human and rodent tissues may not necessarily correlate in the process of aging. © 2007 IBRO.
Source Title: Neuroscience
URI: http://scholarbank.nus.edu.sg/handle/10635/25089
ISSN: 03064522
DOI: 10.1016/j.neuroscience.2006.12.054
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

25
checked on Aug 16, 2018

WEB OF SCIENCETM
Citations

21
checked on Jul 24, 2018

Page view(s)

154
checked on Aug 4, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.