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https://doi.org/10.3390/biomedicines11020508
Title: | Circulating Biomarkers for Prediction of Immunotherapy Response in NSCLC | Authors: | Goh, Kah Yee Cheng, Terence You De Tham, Su Chin Lim, Darren Wan-Teck |
Keywords: | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Medicine, Research & Experimental Pharmacology & Pharmacy Research & Experimental Medicine liquid biopsy biomarkers immunotherapy checkpoint inhibition lung cancer CELL LUNG-CANCER IMMUNE CHECKPOINT INHIBITOR OPEN-LABEL PERIPHERAL-BLOOD TUMOR-CELLS PD-1/PD-L1 PATHWAY LYMPHOCYTE RATIO LIQUID BIOPSY T-CELLS DOCETAXEL |
Issue Date: | Feb-2023 | Publisher: | MDPI | Citation: | Goh, Kah Yee, Cheng, Terence You De, Tham, Su Chin, Lim, Darren Wan-Teck (2023-02). Circulating Biomarkers for Prediction of Immunotherapy Response in NSCLC. BIOMEDICINES 11 (2). ScholarBank@NUS Repository. https://doi.org/10.3390/biomedicines11020508 | Abstract: | Non-small cell lung cancer (NSCLC) constitutes the majority of the lung cancer population and the prognosis is poor. In recent years, immunotherapy has become the standard of care for advanced NSCLC patients as numerous trials demonstrated that immune checkpoint inhibitors (ICI) are more efficacious than conventional chemotherapy. However, only a minority of NSCLC patients benefit from this treatment. Therefore, there is an unmet need for biomarkers that could accurately predict response to immunotherapy. Liquid biopsy allows repeated sampling of blood-based biomarkers in a non-invasive manner for the dynamic monitoring of treatment response. In this review, we summarize the efforts and progress made in the identification of circulating biomarkers that predict immunotherapy benefit for NSCLC patients. We also discuss the challenges with future implementation of circulating biomarkers into clinical practice. | Source Title: | BIOMEDICINES | URI: | https://scholarbank.nus.edu.sg/handle/10635/248896 | ISSN: | 2227-9059 | DOI: | 10.3390/biomedicines11020508 |
Appears in Collections: | Staff Publications Elements |
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