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https://doi.org/10.1002/acn3.729
| Title: | Plasma alpha-synuclein detected by single molecule array is increased in PD | Authors: | Ng, Adeline SL Tan, Yi Jayne Lu, Zhonghao Ng, Ebonne YL Ng, Samuel YE Chia, Nicole SY Setiawan, Fiona Xu, Zheyu Tay, Kay Yaw Prakash, Kumar M Au, Wing Lok Tan, Eng-King Tan, Louis CS |
Keywords: | Science & Technology Life Sciences & Biomedicine Clinical Neurology Neurosciences Neurosciences & Neurology PARKINSONS-DISEASE AGGREGATION |
Issue Date: | Mar-2019 | Publisher: | WILEY | Citation: | Ng, Adeline SL, Tan, Yi Jayne, Lu, Zhonghao, Ng, Ebonne YL, Ng, Samuel YE, Chia, Nicole SY, Setiawan, Fiona, Xu, Zheyu, Tay, Kay Yaw, Prakash, Kumar M, Au, Wing Lok, Tan, Eng-King, Tan, Louis CS (2019-03). Plasma alpha-synuclein detected by single molecule array is increased in PD. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY 6 (3) : 615-619. ScholarBank@NUS Repository. https://doi.org/10.1002/acn3.729 | Abstract: | We utilized ultrasensitive single molecule technology to measure plasma alpha-synuclein in 221 subjects (51 controls, 170 PD). Plasma alpha-synuclein levels were significantly higher in PD than controls (15506.3 vs. 13057.0 pg/mL, P = 0.037), adjusting for age and gender. In PD, alpha-synuclein levels did not vary by H&Y stage or UPDRS motor scores but were significantly higher in PD patients with poorer cognition (MMSE ≤ 25) than controls (P = 0.016, Bonferroni corrected P = 0.047). Alpha-synuclein levels quantified using ultrasensitive single molecule technology discriminate PD from controls and correlate with cognitive severity. These preliminary findings require independent validation to determine the utility of this assay. | Source Title: | ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | URI: | https://scholarbank.nus.edu.sg/handle/10635/248774 | ISSN: | 2328-9503 | DOI: | 10.1002/acn3.729 |
| Appears in Collections: | Staff Publications Elements |
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