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https://doi.org/10.3390/diagnostics11040661
Title: | Gingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia. | Authors: | Chaparro, Alejandra Monckeberg, Maximiliano Realini, Ornella Hernández, Marcela Param, Fernanda Albers, Daniela Ramírez, Valeria Kusanovic, Juan Pedro Romero, Roberto Rice, Gregory Illanes, Sebastian E |
Keywords: | cohort study gestation placental biomarkers pre-eclampsia risk prediction model |
Issue Date: | 7-Apr-2021 | Publisher: | MDPI AG | Citation: | Chaparro, Alejandra, Monckeberg, Maximiliano, Realini, Ornella, Hernández, Marcela, Param, Fernanda, Albers, Daniela, Ramírez, Valeria, Kusanovic, Juan Pedro, Romero, Roberto, Rice, Gregory, Illanes, Sebastian E (2021-04-07). Gingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia.. Diagnostics (Basel) 11 (4) : 661-. ScholarBank@NUS Repository. https://doi.org/10.3390/diagnostics11040661 | Abstract: | Early and innovative diagnostic strategies are required to predict the risk of developing pre-eclampsia (PE). The purpose of this study was to evaluate the performance of gingival crevicular fluid (GCF) placental alkaline phosphatase (PLAP) concentrations to correctly classify women at risk of PE. A prospectively collected, retrospectively stratified cohort study was conducted, with 412 pregnant women recruited at 11-14 weeks of gestation. Physical, obstetrical, and periodontal data were recorded. GCF and blood samples were collected for PLAP determination by ELISA assay. A multiple logistic regression classification model was developed, and the classification efficiency of the model was established. Within the study cohort, 4.3% of pregnancies developed PE. GCF-PLAP concentration was 3- to 6-fold higher than in plasma samples. GCF-PLAP concentrations and systolic blood pressure were greater in women who developed PE (p = 0.015 and p < 0.001, respectively). The performance of the multiparametric model that combines GCF-PLAP concentration and the levels of systolic blood pressure (at 11-14 weeks gestation) showed an association of systolic blood pressure and GCF-PLAP concentrations with the likelihood of developing PE (OR:1.07; 95% CI 1.01-1.11; p = 0.004 and OR:1.008, 95% CI 1.000-1.015; p = 0.034, respectively). The model had a sensitivity of 83%, a specificity of 72%, and positive and negative predictive values of 12% and 99%, respectively. The area under the receiver operating characteristic (AUC-ROC) curve was 0.77 and correctly classified 72% of PE pregnancies. In conclusion, the multivariate classification model developed may be of utility as an aid in identifying pre-symptomatic women who subsequently develop PE. | Source Title: | Diagnostics (Basel) | URI: | https://scholarbank.nus.edu.sg/handle/10635/246507 | ISSN: | 2075-4418 | DOI: | 10.3390/diagnostics11040661 |
Appears in Collections: | Elements Staff Publications |
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