Please use this identifier to cite or link to this item:
https://doi.org/10.3390/diagnostics11040661
DC Field | Value | |
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dc.title | Gingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia. | |
dc.contributor.author | Chaparro, Alejandra | |
dc.contributor.author | Monckeberg, Maximiliano | |
dc.contributor.author | Realini, Ornella | |
dc.contributor.author | Hernández, Marcela | |
dc.contributor.author | Param, Fernanda | |
dc.contributor.author | Albers, Daniela | |
dc.contributor.author | Ramírez, Valeria | |
dc.contributor.author | Kusanovic, Juan Pedro | |
dc.contributor.author | Romero, Roberto | |
dc.contributor.author | Rice, Gregory | |
dc.contributor.author | Illanes, Sebastian E | |
dc.date.accessioned | 2023-12-20T07:16:18Z | |
dc.date.available | 2023-12-20T07:16:18Z | |
dc.date.issued | 2021-04-07 | |
dc.identifier.citation | Chaparro, Alejandra, Monckeberg, Maximiliano, Realini, Ornella, Hernández, Marcela, Param, Fernanda, Albers, Daniela, Ramírez, Valeria, Kusanovic, Juan Pedro, Romero, Roberto, Rice, Gregory, Illanes, Sebastian E (2021-04-07). Gingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia.. Diagnostics (Basel) 11 (4) : 661-. ScholarBank@NUS Repository. https://doi.org/10.3390/diagnostics11040661 | |
dc.identifier.issn | 2075-4418 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/246507 | |
dc.description.abstract | Early and innovative diagnostic strategies are required to predict the risk of developing pre-eclampsia (PE). The purpose of this study was to evaluate the performance of gingival crevicular fluid (GCF) placental alkaline phosphatase (PLAP) concentrations to correctly classify women at risk of PE. A prospectively collected, retrospectively stratified cohort study was conducted, with 412 pregnant women recruited at 11-14 weeks of gestation. Physical, obstetrical, and periodontal data were recorded. GCF and blood samples were collected for PLAP determination by ELISA assay. A multiple logistic regression classification model was developed, and the classification efficiency of the model was established. Within the study cohort, 4.3% of pregnancies developed PE. GCF-PLAP concentration was 3- to 6-fold higher than in plasma samples. GCF-PLAP concentrations and systolic blood pressure were greater in women who developed PE (p = 0.015 and p < 0.001, respectively). The performance of the multiparametric model that combines GCF-PLAP concentration and the levels of systolic blood pressure (at 11-14 weeks gestation) showed an association of systolic blood pressure and GCF-PLAP concentrations with the likelihood of developing PE (OR:1.07; 95% CI 1.01-1.11; p = 0.004 and OR:1.008, 95% CI 1.000-1.015; p = 0.034, respectively). The model had a sensitivity of 83%, a specificity of 72%, and positive and negative predictive values of 12% and 99%, respectively. The area under the receiver operating characteristic (AUC-ROC) curve was 0.77 and correctly classified 72% of PE pregnancies. In conclusion, the multivariate classification model developed may be of utility as an aid in identifying pre-symptomatic women who subsequently develop PE. | |
dc.publisher | MDPI AG | |
dc.source | Elements | |
dc.subject | cohort study | |
dc.subject | gestation | |
dc.subject | placental biomarkers | |
dc.subject | pre-eclampsia | |
dc.subject | risk prediction model | |
dc.type | Article | |
dc.date.updated | 2023-12-20T05:12:21Z | |
dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
dc.description.doi | 10.3390/diagnostics11040661 | |
dc.description.sourcetitle | Diagnostics (Basel) | |
dc.description.volume | 11 | |
dc.description.issue | 4 | |
dc.description.page | 661- | |
dc.published.state | Published online | |
Appears in Collections: | Elements Staff Publications |
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Gingival Crevicular Placental Alkaline Phosphatase Is an Early Pregnancy Biomarker for Pre-Eclampsia. .pdf | 1.72 MB | Adobe PDF | OPEN | None | View/Download |
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