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https://doi.org/10.1002/anie.202307288
Title: | Activatable Type I Photosensitizer with Quenched Photosensitization Pre and Post Photodynamic Therapy | Authors: | Tian, Jianwu Li, Bowen Zhang, Fu Yao, Zhuo Song, Wentao Tang, Yufu Ping, Yuan Liu, Bin |
Keywords: | Science & Technology Physical Sciences Chemistry, Multidisciplinary Chemistry Hypoxia On-Demand Switchable Photosensitizer Photodynamic Therapy Reversible Type I Photosensitizer GENERATION |
Issue Date: | 13-Nov-2023 | Publisher: | WILEY-V C H VERLAG GMBH | Citation: | Tian, Jianwu, Li, Bowen, Zhang, Fu, Yao, Zhuo, Song, Wentao, Tang, Yufu, Ping, Yuan, Liu, Bin (2023-11-13). Activatable Type I Photosensitizer with Quenched Photosensitization Pre and Post Photodynamic Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 62 (46). ScholarBank@NUS Repository. https://doi.org/10.1002/anie.202307288 | Abstract: | The phototoxicity of photosensitizers (PSs) pre and post photodynamic therapy (PDT), and the hypoxic tumor microenvironment are two major problems limiting the application of PDT. While activatable PSs can successfully address the PS phototoxicity pre PDT, and type I PS can generate reactive oxygen species (ROS) effectively in hypoxic environment, very limited approaches are available for addressing the phototoxicity post PDT. There is virtually no solution available to address all these issues using a single design. Herein, we propose a proof-of-concept on-demand switchable photosensitizer with quenched photosensitization pre and post PDT, which could be activated only in tumor hypoxic environment. Particularly, a hypoxia-normoxia cycling responsive type I PS TPFN-AzoCF3 was designed to demonstrate the concept, which was further formulated into TPFN-AzoCF3 nanoparticles (NPs) using DSPE-PEG-2000 as the encapsulation matrix. The NPs could be activated only in hypoxic tumors to generate type I ROS during PDT treatment, but remain non-toxic in normal tissues, pre or after PDT, thus minimizing side effects and improving the therapeutic effect. With promising results in in vitro and in vivo tumor treatment, this presented strategy will pave the way for the design of more on-demand switchable photosensitizers with minimized side effects in the future. | Source Title: | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | URI: | https://scholarbank.nus.edu.sg/handle/10635/246040 | ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.202307288 |
Appears in Collections: | Staff Publications Elements |
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Tian Jianwu-Activatable Type-I Photosensitizer with Quenched Photosensitization Pre and Post Photodynamic Therapy-Angew Chem.docx | 2.56 MB | Microsoft Word XML | OPEN | Post-print | Available on 13-11-2024 |
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