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https://doi.org/10.1016/j.jhepr.2023.100835
Title: | Non-alcoholic fatty liver disease in women – Current knowledge and emerging concepts | Authors: | Eng, PC Forlano, R Tan, T Manousou, P Dhillo, WS Izzi-Engbeaya, C |
Keywords: | Androgens Estrogens Menopause Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Women |
Issue Date: | 1-Oct-2023 | Publisher: | Elsevier BV | Citation: | Eng, PC, Forlano, R, Tan, T, Manousou, P, Dhillo, WS, Izzi-Engbeaya, C (2023-10-01). Non-alcoholic fatty liver disease in women – Current knowledge and emerging concepts. JHEP Reports 5 (10) : 100835-. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jhepr.2023.100835 | Abstract: | Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver disease worldwide, affecting up to 30% of adults. Progression to non-alcoholic steatohepatitis (NASH) is a key risk factor for cirrhosis, hepatocellular carcinoma and cardiovascular events. Alterations in reproductive hormones are linked to the development and/or progression of NAFLD/NASH in women. Women with polycystic ovary syndrome and those with oestrogen deficiency are at increased risk of NAFLD/NASH, with higher mortality rates in older women compared to men of similar ages. NAFLD/NASH is currently the leading indication for liver transplantation in women without hepatocellular carcinoma. Therefore, a better understanding of NAFLD in women is needed to improve outcomes. In this review, we discuss the hormonal and non-hormonal factors that contribute to NAFLD development and progression in women. Furthermore, we highlight areas of focus for clinical practice and for future research. | Source Title: | JHEP Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/245956 | ISSN: | 2589-5559 | DOI: | 10.1016/j.jhepr.2023.100835 |
Appears in Collections: | Staff Publications Elements |
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