Please use this identifier to cite or link to this item:
https://doi.org/10.1136/ejhpharm-2016-001136
Title: | Prolonged argatroban clearance in a critically ill patient with heparin-induced thrombocytopaenia | Authors: | Tee, Caroline Yuen, Yi Ching Lim, Cheryl Yap, Eng Soo |
Keywords: | Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy FAILURE |
Issue Date: | Jul-2017 | Publisher: | BMJ PUBLISHING GROUP | Citation: | Tee, Caroline, Yuen, Yi Ching, Lim, Cheryl, Yap, Eng Soo (2017-07). Prolonged argatroban clearance in a critically ill patient with heparin-induced thrombocytopaenia. EUROPEAN JOURNAL OF HOSPITAL PHARMACY 24 (4) : 242-243. ScholarBank@NUS Repository. https://doi.org/10.1136/ejhpharm-2016-001136 | Abstract: | This is a case of argatroban use in a critically ill patient with heparin-induced thrombocytopaenia (HIT), presenting with unexpectedly prolonged drug clearance possibly secondary to hepatic congestion due to reduced cardiac contractility. A 63-year-old woman from Asia with end-stage renal failure was hospitalised in the critical care unit with non-ST elevation myocardial infarction with underlying triple vessel disease. She was subsequently started on intravenous unfractionated heparin infusion after an intra-aortic balloon pump was inserted. Six days after the initiation of heparin, she developed HIT and argatroban was started for treatment of HIT. Despite starting on the recommended dose of 2μg/kg/min, she developed significantly prolonged activated partial thromboplastin time (aPTT) with delayed clearance. Argatroban was stopped 14 hours after time of initiation in view of the markedly prolonged aPTT (in the range of 145 s), and levels only normalised at approximately 60 hours after argatroban was stopped. | Source Title: | EUROPEAN JOURNAL OF HOSPITAL PHARMACY | URI: | https://scholarbank.nus.edu.sg/handle/10635/245616 | ISSN: | 2047-9956 2047-9964 |
DOI: | 10.1136/ejhpharm-2016-001136 |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Prolonged argatroban clearance in a critically ill patient with heparin-induced thrombocytopaenia.pdf | 367.92 kB | Adobe PDF | OPEN | Published | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.