Please use this identifier to cite or link to this item: https://doi.org/10.1111/sdi.12951
Title: Filter life and safety of heparin-grafted membrane for continuous renal replacement therapy - A randomized controlled trial
Authors: Wong, Emmett Tsz-Yeung 
Ong, Venetia
Remani, Deepa
Wong, Weng-Kin 
Haroon, Sabrina 
Lau, Titus
Nyeo, Hui-Qing
Mukhopadhyay, Amartya 
Tan, Bee-Hong
Chua, Horng-Ruey
Keywords: Science & Technology
Life Sciences & Biomedicine
Urology & Nephrology
acute kidney injury
blood coagulation
critical illness
grafted heparin
heparin
renal replacement therapy
Issue Date: Jul-2021
Publisher: WILEY
Citation: Wong, Emmett Tsz-Yeung, Ong, Venetia, Remani, Deepa, Wong, Weng-Kin, Haroon, Sabrina, Lau, Titus, Nyeo, Hui-Qing, Mukhopadhyay, Amartya, Tan, Bee-Hong, Chua, Horng-Ruey (2021-07). Filter life and safety of heparin-grafted membrane for continuous renal replacement therapy - A randomized controlled trial. SEMINARS IN DIALYSIS 34 (4) : 300-308. ScholarBank@NUS Repository. https://doi.org/10.1111/sdi.12951
Abstract: Polyethyleneimine-layered membrane with grafted heparin (oXiris) may improve filter life during continuous renal replacement therapy (CRRT) in addition to its immunoadsorptive capability, compared with that of conventional membrane. In this single center, prospective, open-label pilot study, we randomized critically ill patients with bleeding risk who underwent anticoagulation-free CRRT, to commence with oXiris or M150 filter with sequential crossover. We examined the filter life with each circuit and its effect on systemic coagulation parameters. We randomized 11 and nine patients to commence CRRT with oXiris and M150 respectively, with 19 oXiris and 20 M150 filter-circuits in all. Patient profiles in both arms were comparable for illness severity and comorbidities. Median filter lives for oXiris versus M150 circuits were 13 h versus 18 h (p = 0.10). Among 11 patients with paired crossover filters, filter lives for 14 oXiris–M150 circuit pairs were 13 h versus 16 h (p = 0.27), and corresponding transmembrane pressures increased to 111 mmHg versus 75 mmHg by 12 h (p = 0.02). Patients’ coagulation parameters were comparable following both filter-circuits. CRRT with oXiris (vs. M150) was independently associated with shorter filter life, adjusted for prescribed dose, vascular access, and coagulopathy. Use of oXiris did not prolong filter life over conventional membrane with no evidence of systemic heparin exposure; significant membrane clogging is observed by 12 h with oXiris.
Source Title: SEMINARS IN DIALYSIS
URI: https://scholarbank.nus.edu.sg/handle/10635/244451
ISSN: 0894-0959
1525-139X
DOI: 10.1111/sdi.12951
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