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https://doi.org/10.1159/000531016
Title: | Quality Assessment of Ultrasound and Magnetic Resonance Imaging for Hepatocellular Carcinoma Surveillance: A Systematic Review and Meta-Analysis | Authors: | Quek, Jingxuan Tan, Darren Jun Hao Chan, Kai En Lim, Wen Hui Ng, Cheng Han Ren, Yi Ping Koh, Teng Kiat Teh, Readon Xiao, Jieling Fu, Clarissa Syn, Nicholas Teng, Margaret Muthiah, Mark Fowler, Kathryn J. Sirlin, Claude B. Loomba, Rohit Huang, Daniel Q. |
Keywords: | Liver cancer Hepatocellular carcinoma Screening Ultrasound Magnetic resonance imaging |
Issue Date: | 11-May-2023 | Publisher: | S. Karger AG | Citation: | Quek, Jingxuan, Tan, Darren Jun Hao, Chan, Kai En, Lim, Wen Hui, Ng, Cheng Han, Ren, Yi Ping, Koh, Teng Kiat, Teh, Readon, Xiao, Jieling, Fu, Clarissa, Syn, Nicholas, Teng, Margaret, Muthiah, Mark, Fowler, Kathryn J., Sirlin, Claude B., Loomba, Rohit, Huang, Daniel Q. (2023-05-11). Quality Assessment of Ultrasound and Magnetic Resonance Imaging for Hepatocellular Carcinoma Surveillance: A Systematic Review and Meta-Analysis. Digestive Diseases. ScholarBank@NUS Repository. https://doi.org/10.1159/000531016 | Rights: | Attribution 4.0 International | Abstract: | Introduction: To achieve early detection and curative treatment options, surveillance imaging for hepatocellular carcinoma (HCC) must remain of quality and without substantial limitations in liver visualization. However, the prevalence of limited liver visualization during HCC surveillance imaging has not been systematically assessed. Utilizing a systematic review and meta-analytic approach, we aimed to determine the prevalence of limited liver visualization during HCC surveillance imaging. Methods: MEDLINE and Embase electronic databases were searched to identify published data on liver visualization limitations of HCC surveillance imaging. An analysis of proportions was pooled using a generalized linear mixed model with Clopper-Pearson intervals. Risk factors were analysed using a generalized mixed model with a logit link and inverse variance weightage. Results: Of 683 records, 10 studies (7,131 patients) met inclusion criteria. Seven studies provided data on liver visualization limitations on ultrasound (US) surveillance exams: prevalence of limited liver visualization was 48.9% (95% CI: 23.5–74.9%) in the overall analysis and 59.2% (95% CI: 24.2–86.9%) in a sensitivity analysis for cirrhotic patients. Meta-regression determined that non-alcoholic fatty liver disease was associated with limited liver visualization on US. Four studies provided data for liver visualization limitations in abbreviated magnetic resonance imaging (aMRI), with inadequate visualization ranging from 5.8% to 19.0%. One study provided data for complete MRI and none for computed tomography. Conclusion: A substantial proportion of US exams performed for HCC surveillance provide limited liver visualization, especially in cirrhosis, which may hinder detection of small observations. Alternative surveillance strategies including aMRI may be appropriate for patients with limited US visualization. | Source Title: | Digestive Diseases | URI: | https://scholarbank.nus.edu.sg/handle/10635/243792 | ISSN: | 0257-2753 1421-9875 |
DOI: | 10.1159/000531016 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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