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https://doi.org/10.1021/acs.orglett.9b01457
| Title: | Protecting-Group-Free Synthesis of Chondroitin 6-Sulfate Disaccharide and Tetrasaccharide | Authors: | Chng, Yong Sheng Tristan, Geordi Yip, George W Lam, Yulin |
Keywords: | Science & Technology Physical Sciences Chemistry, Organic Chemistry SIZE-DEFINED OLIGOMERS STEREOCONTROLLED CONSTRUCTION SULFATE GLYCOSAMINOGLYCAN PROTEOGLYCANS DIVERGENT PROTEINS POLYMER DI |
Issue Date: | 21-Jun-2019 | Publisher: | AMER CHEMICAL SOC | Citation: | Chng, Yong Sheng, Tristan, Geordi, Yip, George W, Lam, Yulin (2019-06-21). Protecting-Group-Free Synthesis of Chondroitin 6-Sulfate Disaccharide and Tetrasaccharide. ORGANIC LETTERS 21 (12) : 4559-4562. ScholarBank@NUS Repository. https://doi.org/10.1021/acs.orglett.9b01457 | Abstract: | Chondroitin 6-sulfate (CS-C) is an important glycosaminoglycan that regulates many physiological functions including the development, progression, and metastasis of cancer. To understand its mechanism of action at the molecular level, CS-C molecules of defined length are required. A protecting group-free synthesis of CS-C disaccharide and tetrasaccharide from the CS-A polymer that involves only three steps and furnishes CS-O disaccharide and tetrasaccharide as intermediates is reported. | Source Title: | ORGANIC LETTERS | URI: | https://scholarbank.nus.edu.sg/handle/10635/242993 | ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/acs.orglett.9b01457 |
| Appears in Collections: | Staff Publications Elements |
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