Please use this identifier to cite or link to this item:
https://doi.org/10.1021/acs.orglett.0c00487
| Title: | H-Phosphonate Synthesis and Biological Evaluation of an Immunomodulatory Phosphoglycolipid from Thermophilic Bacteria | Authors: | Gan, Chin Heng Wijaya, Hadhi Li, Lan-Hui Wei, Chih-Feng Peng, Yi-Jen Wu, Shih-Hsiung Hua, Kuo-Feng Lam, Yulin |
Keywords: | Science & Technology Physical Sciences Chemistry, Organic Chemistry PHOSPHATIDYLINOSITOL THERMUS |
Issue Date: | 3-Apr-2020 | Publisher: | AMER CHEMICAL SOC | Citation: | Gan, Chin Heng, Wijaya, Hadhi, Li, Lan-Hui, Wei, Chih-Feng, Peng, Yi-Jen, Wu, Shih-Hsiung, Hua, Kuo-Feng, Lam, Yulin (2020-04-03). H-Phosphonate Synthesis and Biological Evaluation of an Immunomodulatory Phosphoglycolipid from Thermophilic Bacteria. ORGANIC LETTERS 22 (7) : 2569-2573. ScholarBank@NUS Repository. https://doi.org/10.1021/acs.orglett.0c00487 | Abstract: | The synthesis of a library of bacterial phosphoglycolipid, PGL-1, is described. Key features of the synthesis include regioselective esterification of the primary alcohol of the diacylglycerol moiety and an H-phosphonate method to install the phosphate in PGL-1 in comparison with earlier reported procedures. A representative set of PGL-1 analogues was prepared and evaluated for their biological activities. Results showed that the immunological activity of PGL-1 is dependent on the chain lengths of the fatty acids. | Source Title: | ORGANIC LETTERS | URI: | https://scholarbank.nus.edu.sg/handle/10635/242990 | ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/acs.orglett.0c00487 |
| Appears in Collections: | Elements Staff Publications |
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