Please use this identifier to cite or link to this item: https://doi.org/10.1364/BOE.7.001116
Title: Integrated Mueller-matrix near-infrared imaging and point-wise spectroscopy improves colonic cancer detection
Authors: Wang, Jianfeng 
Zheng, Wei
Lin, Kan 
Huang, Zhiwei 
Keywords: Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemical Research Methods
Optics
Radiology, Nuclear Medicine & Medical Imaging
Biochemistry & Molecular Biology
CONFOCAL RAMAN-SPECTROSCOPY
IN-VIVO
POLARIZED-LIGHT
REFLECTANCE SPECTROSCOPY
SIMULTANEOUS FINGERPRINT
COLORECTAL-CANCER
TISSUE
ENDOSCOPY
WATER
PARAMETERS
Issue Date: 1-Apr-2016
Publisher: OPTICAL SOC AMER
Citation: Wang, Jianfeng, Zheng, Wei, Lin, Kan, Huang, Zhiwei (2016-04-01). Integrated Mueller-matrix near-infrared imaging and point-wise spectroscopy improves colonic cancer detection. BIOMEDICAL OPTICS EXPRESS 7 (4) : 1116-1126. ScholarBank@NUS Repository. https://doi.org/10.1364/BOE.7.001116
Abstract: We report the development and implementation of a unique integrated Mueller-matrix (MM) near-infrared (NIR) imaging and Muellermatrix point-wise diffuse reflectance (DR) spectroscopy technique for improving colonic cancer detection and diagnosis. Point-wise MM DR spectra can be acquired from any suspicious tissue areas indicated by MM imaging. A total of 30 paired colonic tissue specimens (normal vs. cancer) were measured using the integrated MM imaging and point-wise MM DR spectroscopy system. Polar decomposition algorithms are employed on the acquired images and spectra to derive three polarization metrics including depolarization, diattentuation and retardance for colonic tissue characterization. The decomposition results show that tissue depolarization and retardance are significantly decreased (p<0.001, paired 2-sided Student’s t-test, n = 30); while the tissue diattentuation is significantly increased (p<0.001, paired 2-sided Student’s t-test, n = 30) associated with colonic cancer. Further partial least squares discriminant analysis (PLS-DA) and leave-one tissue site-out, cross validation (LOSCV) show that the combination of the three polarization metrics provide the best diagnostic accuracy of 95.0% (sensitivity: 93.3%, and specificity: 96.7%) compared to either of the three polarization metrics (sensitivities of 93.3%, 83.3%, and 80.0%; and specificities of 90.0%, 96.7%, and 80.0%, respectively, for the depolarization, diattentuation and retardance metrics) for colonic cancer detection. This work suggests that the integrated MM NIR imaging and point-wise MM NIR diffuse reflectance spectroscopy has the potential to improve the early detection and diagnosis of malignant lesions in the colon.
Source Title: BIOMEDICAL OPTICS EXPRESS
URI: https://scholarbank.nus.edu.sg/handle/10635/242023
ISSN: 2156-7085,2156-7085
DOI: 10.1364/BOE.7.001116
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