Please use this identifier to cite or link to this item: https://doi.org/10.1364/BOE.7.001116
DC FieldValue
dc.titleIntegrated Mueller-matrix near-infrared imaging and point-wise spectroscopy improves colonic cancer detection
dc.contributor.authorWang, Jianfeng
dc.contributor.authorZheng, Wei
dc.contributor.authorLin, Kan
dc.contributor.authorHuang, Zhiwei
dc.date.accessioned2023-06-15T02:07:34Z
dc.date.available2023-06-15T02:07:34Z
dc.date.issued2016-04-01
dc.identifier.citationWang, Jianfeng, Zheng, Wei, Lin, Kan, Huang, Zhiwei (2016-04-01). Integrated Mueller-matrix near-infrared imaging and point-wise spectroscopy improves colonic cancer detection. BIOMEDICAL OPTICS EXPRESS 7 (4) : 1116-1126. ScholarBank@NUS Repository. https://doi.org/10.1364/BOE.7.001116
dc.identifier.issn2156-7085,2156-7085
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/242023
dc.description.abstractWe report the development and implementation of a unique integrated Mueller-matrix (MM) near-infrared (NIR) imaging and Muellermatrix point-wise diffuse reflectance (DR) spectroscopy technique for improving colonic cancer detection and diagnosis. Point-wise MM DR spectra can be acquired from any suspicious tissue areas indicated by MM imaging. A total of 30 paired colonic tissue specimens (normal vs. cancer) were measured using the integrated MM imaging and point-wise MM DR spectroscopy system. Polar decomposition algorithms are employed on the acquired images and spectra to derive three polarization metrics including depolarization, diattentuation and retardance for colonic tissue characterization. The decomposition results show that tissue depolarization and retardance are significantly decreased (p<0.001, paired 2-sided Student’s t-test, n = 30); while the tissue diattentuation is significantly increased (p<0.001, paired 2-sided Student’s t-test, n = 30) associated with colonic cancer. Further partial least squares discriminant analysis (PLS-DA) and leave-one tissue site-out, cross validation (LOSCV) show that the combination of the three polarization metrics provide the best diagnostic accuracy of 95.0% (sensitivity: 93.3%, and specificity: 96.7%) compared to either of the three polarization metrics (sensitivities of 93.3%, 83.3%, and 80.0%; and specificities of 90.0%, 96.7%, and 80.0%, respectively, for the depolarization, diattentuation and retardance metrics) for colonic cancer detection. This work suggests that the integrated MM NIR imaging and point-wise MM NIR diffuse reflectance spectroscopy has the potential to improve the early detection and diagnosis of malignant lesions in the colon.
dc.language.isoen
dc.publisherOPTICAL SOC AMER
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectPhysical Sciences
dc.subjectBiochemical Research Methods
dc.subjectOptics
dc.subjectRadiology, Nuclear Medicine & Medical Imaging
dc.subjectBiochemistry & Molecular Biology
dc.subjectCONFOCAL RAMAN-SPECTROSCOPY
dc.subjectIN-VIVO
dc.subjectPOLARIZED-LIGHT
dc.subjectREFLECTANCE SPECTROSCOPY
dc.subjectSIMULTANEOUS FINGERPRINT
dc.subjectCOLORECTAL-CANCER
dc.subjectTISSUE
dc.subjectENDOSCOPY
dc.subjectWATER
dc.subjectPARAMETERS
dc.typeArticle
dc.date.updated2023-06-06T02:41:43Z
dc.contributor.departmentBIOENGINEERING
dc.contributor.departmentBIOMEDICAL ENGINEERING
dc.description.doi10.1364/BOE.7.001116
dc.description.sourcetitleBIOMEDICAL OPTICS EXPRESS
dc.description.volume7
dc.description.issue4
dc.description.page1116-1126
dc.description.placeUnited States
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Integrated Mueller-matrix near-infrared imaging and point-wise spectroscopy improves colonic cancer detection.pdf2.87 MBAdobe PDF

OPEN

PublishedView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.