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https://doi.org/10.1038/s41418-023-01153-w
| Title: | Apoptotic cell death in disease—Current understanding of the NCCD 2023 | Authors: | Vitale, I Pietrocola, F Guilbaud, E Aaronson, SA Abrams, JM Adam, D Agostini, M Agostinis, P Alnemri, ES Altucci, L Amelio, I Andrews, DW Aqeilan, RI Arama, E Baehrecke, EH Balachandran, S Bano, D Barlev, NA Bartek, J Bazan, NG Becker, C Bernassola, F Bertrand, MJM Bianchi, ME Blagosklonny, MV Blander, JM Blandino, G Blomgren, K Borner, C Bortner, CD Bove, P Boya, P Brenner, C Broz, P Brunner, T Damgaard, RB Calin, GA Campanella, M Candi, E Carbone, M Carmona-Gutierrez, D Cecconi, F Chan, FKM Chen, GQ Chen, Q Chen, YH Cheng, EH Chipuk, JE Cidlowski, JA Ciechanover, A Ciliberto, G Conrad, M Cubillos-Ruiz, JR Czabotar, PE D’Angiolella, V Daugaard, M Dawson, TM Dawson, VL De Maria, R De Strooper, B Debatin, KM Deberardinis, RJ Degterev, A Del Sal, G Deshmukh, M Di Virgilio, F Diederich, M Dixon, SJ Dynlacht, BD El-Deiry, WS Elrod, JW Engeland, K Fimia, GM Galassi, C Ganini, C Garcia-Saez, AJ Garg, AD Garrido, C Gavathiotis, E Gerlic, M Ghosh, S Green, DR Greene, LA Gronemeyer, H Häcker, G Hajnóczky, G Hardwick, JM Haupt, Y He, S Heery, DM Hengartner, MO Hetz, C Hildeman, DA Ichijo, H Inoue, S Jäättelä, M Janic, A Joseph, B Jost, PJ Kanneganti, TD |
Keywords: | Animals Humans Apoptosis Cell Death Caspases Carcinogenesis Mammals |
Issue Date: | 1-May-2023 | Publisher: | Springer Science and Business Media LLC | Citation: | Vitale, I, Pietrocola, F, Guilbaud, E, Aaronson, SA, Abrams, JM, Adam, D, Agostini, M, Agostinis, P, Alnemri, ES, Altucci, L, Amelio, I, Andrews, DW, Aqeilan, RI, Arama, E, Baehrecke, EH, Balachandran, S, Bano, D, Barlev, NA, Bartek, J, Bazan, NG, Becker, C, Bernassola, F, Bertrand, MJM, Bianchi, ME, Blagosklonny, MV, Blander, JM, Blandino, G, Blomgren, K, Borner, C, Bortner, CD, Bove, P, Boya, P, Brenner, C, Broz, P, Brunner, T, Damgaard, RB, Calin, GA, Campanella, M, Candi, E, Carbone, M, Carmona-Gutierrez, D, Cecconi, F, Chan, FKM, Chen, GQ, Chen, Q, Chen, YH, Cheng, EH, Chipuk, JE, Cidlowski, JA, Ciechanover, A, Ciliberto, G, Conrad, M, Cubillos-Ruiz, JR, Czabotar, PE, D’Angiolella, V, Daugaard, M, Dawson, TM, Dawson, VL, De Maria, R, De Strooper, B, Debatin, KM, Deberardinis, RJ, Degterev, A, Del Sal, G, Deshmukh, M, Di Virgilio, F, Diederich, M, Dixon, SJ, Dynlacht, BD, El-Deiry, WS, Elrod, JW, Engeland, K, Fimia, GM, Galassi, C, Ganini, C, Garcia-Saez, AJ, Garg, AD, Garrido, C, Gavathiotis, E, Gerlic, M, Ghosh, S, Green, DR, Greene, LA, Gronemeyer, H, Häcker, G, Hajnóczky, G, Hardwick, JM, Haupt, Y, He, S, Heery, DM, Hengartner, MO, Hetz, C, Hildeman, DA, Ichijo, H, Inoue, S, Jäättelä, M, Janic, A, Joseph, B, Jost, PJ, Kanneganti, TD (2023-05-01). Apoptotic cell death in disease—Current understanding of the NCCD 2023. Cell Death and Differentiation 30 (5) : 1097-1154. ScholarBank@NUS Repository. https://doi.org/10.1038/s41418-023-01153-w | Abstract: | Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease. | Source Title: | Cell Death and Differentiation | URI: | https://scholarbank.nus.edu.sg/handle/10635/241907 | ISSN: | 1350-9047 1476-5403 |
DOI: | 10.1038/s41418-023-01153-w |
| Appears in Collections: | Staff Publications Elements |
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| Apoptotic cell death in disease-Current understanding of the NCCD 2023.pdf | Published version | 3.15 MB | Adobe PDF | CLOSED | Published |
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