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https://doi.org/10.3390/vaccines10020225
Title: | Human Milk Antibodies after BNT162b2 Vaccination Exhibit Reduced Binding against SARS-CoV-2 Variants of Concern | Authors: | Low, Jia Ming Gu, Yue Ng, Melissa Shu Feng Wang, Liang Wei Amin, Zubair Zhong, Youjia MacAry, Paul A |
Keywords: | Science & Technology Life Sciences & Biomedicine Immunology Medicine, Research & Experimental Research & Experimental Medicine breast milk antibodies passive immunity Pfizer vaccination COVID-19 immunoglobin A BNT162b2 Comirnaty tozinameran |
Issue Date: | 1-Feb-2022 | Publisher: | MDPI | Citation: | Low, Jia Ming, Gu, Yue, Ng, Melissa Shu Feng, Wang, Liang Wei, Amin, Zubair, Zhong, Youjia, MacAry, Paul A (2022-02-01). Human Milk Antibodies after BNT162b2 Vaccination Exhibit Reduced Binding against SARS-CoV-2 Variants of Concern. VACCINES 10 (2). ScholarBank@NUS Repository. https://doi.org/10.3390/vaccines10020225 | Abstract: | SARS-CoV-2-specific antibody responses are engendered in human milk after BNT162b2 vaccination. However, the emergence of variants of concern (VOCs) raises concerns about the specificity of and potential cross-protection mediated by milk antibody responses, which are crucial for passive immunity transferred from breastfeeding mothers to their infants. In this study, we collected milk samples at three different time points pre-and post-vaccination, and measured milk IgA antibody binding to the receptor binding domain (RBD) of the original Wuhan-Hu-1 strain, and the four VOCs, namely Alpha, Beta, Gamma and Delta. We report a significant level of anti-RBD IgA in milk collected at 4–6 weeks after the second dose of vaccination compared to pre-vaccination. We observed around a 30% reduction in binding to most VOCs, including the major circulating Delta variant, compared to the original Wuhan-Hu-1 strain. As COVID-19 vaccines may take some time to be approved for infants, these individuals remain at risk for severe disease and rely mainly on transferred passive immunity. Our findings support the current recommendations for vaccinating lactating women with the aim of transferring mucosal immunity to breastfeeding infants. | Source Title: | VACCINES | URI: | https://scholarbank.nus.edu.sg/handle/10635/239494 | ISSN: | 2076-393X | DOI: | 10.3390/vaccines10020225 |
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