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https://doi.org/10.1016/j.jhazmat.2022.130690
Title: | Wastewater surveillance of SARS-CoV-2 and chemical markers in campus dormitories in an evolving COVID − 19 pandemic | Authors: | Mohapatra, S Bhatia, S Senaratna, KYK Jong, MC Lim, CMB Gangesh, GR Lee, JX Giek, GS Cheung, C Yutao, L Luhua, Y Yong, NH Peng, LC Wong, JCC Ching, NL Gin, KYH |
Keywords: | Disinfectants Emerging contaminants SARS-CoV-2 University campus Wastewater-based epidemiology Humans SARS-CoV-2 COVID-19 Wastewater Pandemics Chromatography, Liquid RNA, Viral Wastewater-Based Epidemiological Monitoring Tandem Mass Spectrometry Anti-Bacterial Agents Disinfectants |
Issue Date: | 15-Mar-2023 | Publisher: | Elsevier BV | Citation: | Mohapatra, S, Bhatia, S, Senaratna, KYK, Jong, MC, Lim, CMB, Gangesh, GR, Lee, JX, Giek, GS, Cheung, C, Yutao, L, Luhua, Y, Yong, NH, Peng, LC, Wong, JCC, Ching, NL, Gin, KYH (2023-03-15). Wastewater surveillance of SARS-CoV-2 and chemical markers in campus dormitories in an evolving COVID − 19 pandemic. Journal of Hazardous Materials 446 : 130690-. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jhazmat.2022.130690 | Abstract: | In this study, we report the implementation of a comprehensive wastewater surveillance testing program at a university campus in Singapore to identify Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infected individuals and the usage of pharmaceuticals and personal care products (PPCPs) as well as other emerging contaminants (ECs). This unique co-monitoring program simultaneously measured SARS-CoV-2 with chemical markers/contaminants as the COVID-19 situation evolved from pandemic to endemic stages, following a nationwide mass vaccination drive. SARS-CoV-2 RNA concentrations in wastewater from campus dormitories were measured using real-time reverse transcription-polymerase chain reaction (RT-qPCR) and corroborated with the number of symptomatic COVID-19 cases confirmed with the antigen rapid test (ART). Consistent results were observed where the concentrations of SARS-CoV-2 RNA detected in wastewater increased proportionately with the number of COVID-19 infected individuals residing on campus. Similarly, a wide range of ECs, including disinfectants and antibiotics, were detected through sensitive liquid chromatography with tandem mass spectrometry (LC-MS/MS) techniques to establish PPCPs consumption patterns during various stages of the COVID-19 pandemic in Singapore. Statistical correlation of SARS-CoV-2 RNA was observed with few ECs belonging to disinfectants, PCPs and antibiotics. A high concentration of disinfectants and subsequent positive correlation with the number of reported cases on the university campus indicates that disinfectants could serve as a chemical marker during such unprecedented times. | Source Title: | Journal of Hazardous Materials | URI: | https://scholarbank.nus.edu.sg/handle/10635/239274 | ISSN: | 0304-3894 1873-3336 |
DOI: | 10.1016/j.jhazmat.2022.130690 |
Appears in Collections: | Elements Staff Publications |
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