Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers15030896
Title: Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current Literature
Authors: de Kleijn, Bertram J
Heldens, Gijs TN
Herruer, Jasmijn M
Sier, Cornelis FM
Piazza, Cesare
de Bree, Remco
Guntinas-Lichius, Orlando
Kowalski, Luiz P
Vander Poorten, Vincent
Rodrigo, Juan P
Zidar, Nina
Nathan, Cherie-Ann
Tsang, Raymond K 
Golusinski, Pawel
Shaha, Ashok R
Ferlito, Alfio
Takes, Robert P
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
intraoperative imaging
narrow band imaging
high resolution microendoscopic imaging
confocal laser endomicroscopy
ultrasound
(auto) fluorescence imaging
augmented reality
transoral surgery
frozen section analysis
computed tomography
TRANSORAL ROBOTIC SURGERY
CONFOCAL LASER ENDOMICROSCOPY
ORAL-CANCER
RAMAN-SPECTROSCOPY
LOCAL RECURRENCE
NECK
HEAD
CARCINOMA
CAVITY
TISSUE
Issue Date: 1-Feb-2023
Publisher: MDPI
Citation: de Kleijn, Bertram J, Heldens, Gijs TN, Herruer, Jasmijn M, Sier, Cornelis FM, Piazza, Cesare, de Bree, Remco, Guntinas-Lichius, Orlando, Kowalski, Luiz P, Vander Poorten, Vincent, Rodrigo, Juan P, Zidar, Nina, Nathan, Cherie-Ann, Tsang, Raymond K, Golusinski, Pawel, Shaha, Ashok R, Ferlito, Alfio, Takes, Robert P (2023-02-01). Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current Literature. CANCERS 15 (3). ScholarBank@NUS Repository. https://doi.org/10.3390/cancers15030896
Abstract: Inadequate resection margins in head and neck squamous cell carcinoma surgery necessitate adjuvant therapies such as re-resection and radiotherapy with or without chemotherapy and imply increasing morbidity and worse prognosis. On the other hand, taking larger margins by extending the resection also leads to avoidable increased morbidity. Oropharyngeal squamous cell carcinomas (OPSCCs) are often difficult to access; resections are limited by anatomy and functionality and thus carry an increased risk for close or positive margins. Therefore, there is a need to improve intraoperative assessment of resection margins. Several intraoperative techniques are available, but these often lead to prolonged operative time and are only suitable for a subgroup of patients. In recent years, new diagnostic tools have been the subject of investigation. This study reviews the available literature on intraoperative techniques to improve resection margins for OPSCCs. A literature search was performed in Embase, PubMed, and Cochrane. Narrow band imaging (NBI), high-resolution microendoscopic imaging, confocal laser endomicroscopy, frozen section analysis (FSA), ultrasound (US), computed tomography scan (CT), (auto) fluorescence imaging (FI), and augmented reality (AR) have all been used for OPSCC. NBI, FSA, and US are most commonly used and increase the rate of negative margins. Other techniques will become available in the future, of which fluorescence imaging has high potential for use with OPSCC.
Source Title: CANCERS
URI: https://scholarbank.nus.edu.sg/handle/10635/238340
ISSN: 2072-6694
2072-6694
DOI: 10.3390/cancers15030896
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