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https://doi.org/10.3390/cancers15030896
Title: | Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current Literature | Authors: | de Kleijn, Bertram J Heldens, Gijs TN Herruer, Jasmijn M Sier, Cornelis FM Piazza, Cesare de Bree, Remco Guntinas-Lichius, Orlando Kowalski, Luiz P Vander Poorten, Vincent Rodrigo, Juan P Zidar, Nina Nathan, Cherie-Ann Tsang, Raymond K Golusinski, Pawel Shaha, Ashok R Ferlito, Alfio Takes, Robert P |
Keywords: | Science & Technology Life Sciences & Biomedicine Oncology intraoperative imaging narrow band imaging high resolution microendoscopic imaging confocal laser endomicroscopy ultrasound (auto) fluorescence imaging augmented reality transoral surgery frozen section analysis computed tomography TRANSORAL ROBOTIC SURGERY CONFOCAL LASER ENDOMICROSCOPY ORAL-CANCER RAMAN-SPECTROSCOPY LOCAL RECURRENCE NECK HEAD CARCINOMA CAVITY TISSUE |
Issue Date: | 1-Feb-2023 | Publisher: | MDPI | Citation: | de Kleijn, Bertram J, Heldens, Gijs TN, Herruer, Jasmijn M, Sier, Cornelis FM, Piazza, Cesare, de Bree, Remco, Guntinas-Lichius, Orlando, Kowalski, Luiz P, Vander Poorten, Vincent, Rodrigo, Juan P, Zidar, Nina, Nathan, Cherie-Ann, Tsang, Raymond K, Golusinski, Pawel, Shaha, Ashok R, Ferlito, Alfio, Takes, Robert P (2023-02-01). Intraoperative Imaging Techniques to Improve Surgical Resection Margins of Oropharyngeal Squamous Cell Cancer: A Comprehensive Review of Current Literature. CANCERS 15 (3). ScholarBank@NUS Repository. https://doi.org/10.3390/cancers15030896 | Abstract: | Inadequate resection margins in head and neck squamous cell carcinoma surgery necessitate adjuvant therapies such as re-resection and radiotherapy with or without chemotherapy and imply increasing morbidity and worse prognosis. On the other hand, taking larger margins by extending the resection also leads to avoidable increased morbidity. Oropharyngeal squamous cell carcinomas (OPSCCs) are often difficult to access; resections are limited by anatomy and functionality and thus carry an increased risk for close or positive margins. Therefore, there is a need to improve intraoperative assessment of resection margins. Several intraoperative techniques are available, but these often lead to prolonged operative time and are only suitable for a subgroup of patients. In recent years, new diagnostic tools have been the subject of investigation. This study reviews the available literature on intraoperative techniques to improve resection margins for OPSCCs. A literature search was performed in Embase, PubMed, and Cochrane. Narrow band imaging (NBI), high-resolution microendoscopic imaging, confocal laser endomicroscopy, frozen section analysis (FSA), ultrasound (US), computed tomography scan (CT), (auto) fluorescence imaging (FI), and augmented reality (AR) have all been used for OPSCC. NBI, FSA, and US are most commonly used and increase the rate of negative margins. Other techniques will become available in the future, of which fluorescence imaging has high potential for use with OPSCC. | Source Title: | CANCERS | URI: | https://scholarbank.nus.edu.sg/handle/10635/238340 | ISSN: | 2072-6694 2072-6694 |
DOI: | 10.3390/cancers15030896 |
Appears in Collections: | Staff Publications Elements |
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