Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.neubiorev.2022.104560
Title: | Test, rinse, repeat: A review of carryover effects in rodent behavioral assays | Authors: | Cnops, Vanja Iyer, Vinaya Rajagopal Parathy, Nageiswari Wong, Peiyan Dawe, Gavin S |
Keywords: | Science & Technology Life Sciences & Biomedicine Behavioral Sciences Neurosciences Neurosciences & Neurology Behavioral phenotyping Anxiety Cognition Depression Habituation Aging Inter-test interval Longitudinal testing Testing effects TAIL-SUSPENSION TEST ELEVATED PLUS-MAZE ONE-TRIAL TOLERANCE ACOUSTIC STARTLE RESPONSE FORCED SWIMMING TEST PREPULSE INHIBITION DEFICITS MEDIAL PREFRONTAL CORTEX TRAUMATIC BRAIN-INJURY HIPPOCAMPAL ACETYLCHOLINE-RELEASE TRANSMITTED FOOD PREFERENCES |
Issue Date: | 23-Feb-2022 | Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | Citation: | Cnops, Vanja, Iyer, Vinaya Rajagopal, Parathy, Nageiswari, Wong, Peiyan, Dawe, Gavin S (2022-02-23). Test, rinse, repeat: A review of carryover effects in rodent behavioral assays. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 135. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neubiorev.2022.104560 | Abstract: | Behavioral phenotyping has been gaining prominence due to the increased use of transgenic animal models of neurological disorders. Repeated testing in the same cohort of animals can reduce the overall number of animals used and is desired especially when animal numbers are difficult to obtain as well as for studies involving within-subject design such as drug treatments or aging. This review aims to provide researchers with a comprehensive overview of the carryover effects when subjecting the same set of animals to the same behavioral test. We have focused on three behavioral domains of testing: anxiety, cognition and depression. Based on a review of the literature and our own experiences as a neurobehavioral core facility, we have found that manipulating inter-test interval, environmental contextual cues and stimuli can mitigate the carryover effects to a large extent, although there are certain tests that still show strong residual effects. In addition, the effects of strain on carryover effects from repeated testing are also discussed in this review. | Source Title: | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | URI: | https://scholarbank.nus.edu.sg/handle/10635/238301 | ISSN: | 0149-7634 1873-7528 |
DOI: | 10.1016/j.neubiorev.2022.104560 |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
1-s2.0-S0149763422000495-main.pdf | 787.87 kB | Adobe PDF | OPEN | Published | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.