Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.neubiorev.2022.104560
DC Field | Value | |
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dc.title | Test, rinse, repeat: A review of carryover effects in rodent behavioral assays | |
dc.contributor.author | Cnops, Vanja | |
dc.contributor.author | Iyer, Vinaya Rajagopal | |
dc.contributor.author | Parathy, Nageiswari | |
dc.contributor.author | Wong, Peiyan | |
dc.contributor.author | Dawe, Gavin S | |
dc.date.accessioned | 2023-03-22T02:54:15Z | |
dc.date.available | 2023-03-22T02:54:15Z | |
dc.date.issued | 2022-02-23 | |
dc.identifier.citation | Cnops, Vanja, Iyer, Vinaya Rajagopal, Parathy, Nageiswari, Wong, Peiyan, Dawe, Gavin S (2022-02-23). Test, rinse, repeat: A review of carryover effects in rodent behavioral assays. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 135. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neubiorev.2022.104560 | |
dc.identifier.issn | 0149-7634 | |
dc.identifier.issn | 1873-7528 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/238301 | |
dc.description.abstract | Behavioral phenotyping has been gaining prominence due to the increased use of transgenic animal models of neurological disorders. Repeated testing in the same cohort of animals can reduce the overall number of animals used and is desired especially when animal numbers are difficult to obtain as well as for studies involving within-subject design such as drug treatments or aging. This review aims to provide researchers with a comprehensive overview of the carryover effects when subjecting the same set of animals to the same behavioral test. We have focused on three behavioral domains of testing: anxiety, cognition and depression. Based on a review of the literature and our own experiences as a neurobehavioral core facility, we have found that manipulating inter-test interval, environmental contextual cues and stimuli can mitigate the carryover effects to a large extent, although there are certain tests that still show strong residual effects. In addition, the effects of strain on carryover effects from repeated testing are also discussed in this review. | |
dc.language.iso | en | |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Behavioral Sciences | |
dc.subject | Neurosciences | |
dc.subject | Neurosciences & Neurology | |
dc.subject | Behavioral phenotyping | |
dc.subject | Anxiety | |
dc.subject | Cognition | |
dc.subject | Depression | |
dc.subject | Habituation | |
dc.subject | Aging | |
dc.subject | Inter-test interval | |
dc.subject | Longitudinal testing | |
dc.subject | Testing effects | |
dc.subject | TAIL-SUSPENSION TEST | |
dc.subject | ELEVATED PLUS-MAZE | |
dc.subject | ONE-TRIAL TOLERANCE | |
dc.subject | ACOUSTIC STARTLE RESPONSE | |
dc.subject | FORCED SWIMMING TEST | |
dc.subject | PREPULSE INHIBITION DEFICITS | |
dc.subject | MEDIAL PREFRONTAL CORTEX | |
dc.subject | TRAUMATIC BRAIN-INJURY | |
dc.subject | HIPPOCAMPAL ACETYLCHOLINE-RELEASE | |
dc.subject | TRANSMITTED FOOD PREFERENCES | |
dc.type | Review | |
dc.date.updated | 2023-03-22T02:11:39Z | |
dc.contributor.department | PHARMACOLOGY | |
dc.description.doi | 10.1016/j.neubiorev.2022.104560 | |
dc.description.sourcetitle | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | |
dc.description.volume | 135 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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