Please use this identifier to cite or link to this item: https://doi.org/10.1002/jha2.618
Title: Procoagulant factors and future risk of arterial cardiovascular disease in patients with prior venous thrombosis: A cohort study.
Authors: Yap, Eng Soo 
Lijfering, Willem M
Timp, Jasmijn F
Rosendaal, Frits R
Cannegieter, Suzanne C
Scheres, Luuk JJ
Keywords: cardiovascular disease
coagulation factors
epidemiology
risk factors
venous thrombosis
Issue Date: Feb-2023
Publisher: Wiley
Citation: Yap, Eng Soo, Lijfering, Willem M, Timp, Jasmijn F, Rosendaal, Frits R, Cannegieter, Suzanne C, Scheres, Luuk JJ (2023-02). Procoagulant factors and future risk of arterial cardiovascular disease in patients with prior venous thrombosis: A cohort study.. EJHaem 4 (1) : 3-Dec. ScholarBank@NUS Repository. https://doi.org/10.1002/jha2.618
Abstract: Patients with venous thrombosis (VT) are at increased risk of future arterial cardiovascular disease (CVD) (i.e., myocardial infarction, ischemic stroke or peripheral artery disease). We investigated whether shared risk factors for VT and CVD are associated with the levels of procoagulant factors (fibrinogen, factor VIII, and von Willebrand factor), and whether the relationship between these risk factors and subsequent CVD was mediated through these procoagulant factors in patients with VT. In a follow-up study consisting of 4956 patients with VT, 2176 patients (44%) provided blood samples and were linked to the Dutch Hospital registry of Statistics Netherlands to identify hospital admissions or procedures for subsequent CVD. In total, 52 CVD events occurred over a follow-up of 11,124 years, with an incidence rate of 4.7 per 1000 patient years (95% confidence intervals 3.5-6.1). Increasing age, male sex, smoking history, major illnesses, dyslipidemia, and impaired fasting glucose levels were associated with increased CVD risk. Procoagulant factor levels were also associated with CVD risk. When adjusted for these procoagulant factors, the association between the risk factors and CVD attenuated partially. This study provides evidence that procoagulant factors can partially explain the association between increased risks of subsequent CVD in patients with previous VT.
Source Title: EJHaem
URI: https://scholarbank.nus.edu.sg/handle/10635/237845
ISSN: 26886146
26886146
DOI: 10.1002/jha2.618
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