Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12959-017-0155-z
Title: The diagnosis and treatment of venous thromboembolism in asian patients
Authors: Wang, Kang-Ling
Yap, Eng Soo 
Goto, Shinya
Zhang, Shu
Siu, Chung-Wah
Chiang, Chern-En
Keywords: Science & Technology
Life Sciences & Biomedicine
Hematology
Peripheral Vascular Disease
Cardiovascular System & Cardiology
Venous thromboembolism
Asia
Epidemiology
Risk factors
Treatment
DEEP-VEIN-THROMBOSIS
SUSPECTED PULMONARY-EMBOLISM
DIRECT ORAL ANTICOAGULANTS
TOTAL KNEE ARTHROPLASTY
PROTEIN-S DEFICIENCIES
RISK-FACTORS
D-DIMER
ORTHOPEDIC-SURGERY
CHINESE PATIENTS
JAPANESE PATIENTS
Issue Date: 18-Jan-2018
Publisher: BMC
Citation: Wang, Kang-Ling, Yap, Eng Soo, Goto, Shinya, Zhang, Shu, Siu, Chung-Wah, Chiang, Chern-En (2018-01-18). The diagnosis and treatment of venous thromboembolism in asian patients. THROMBOSIS JOURNAL 16 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12959-017-0155-z
Abstract: Although the incidence of venous thromboembolism (VTE) in Asian populations is lower than in Western countries, the overall burden of VTE in Asia has been considerably underestimated. Factors that may explain the lower prevalence of VTE in Asian populations relative to Western populations include the limited availability of epidemiological data in Asia, ethnic differences in the genetic predisposition to VTE, underdiagnoses, low awareness toward thrombotic disease, and possibly less symptomatic VTE in Asian patients. The clinical assessment, diagnostic testing, and therapeutic considerations for VTE are, in general, the same in Asian populations as they are in Western populations. The management of VTE is based upon balancing the treatment benefits against the risk of bleeding. This is an especially important consideration for Asian populations because of increased risk of intracranial hemorrhage with vitamin K antagonists. Non-vitamin K antagonist oral anticoagulants have shown advantages over current treatment modalities with respect to bleeding outcomes in major phase 3 clinical trials, including in Asian populations. Although anticoagulant therapy has been shown to reduce the risk of postoperative VTE in Western populations, VTE prophylaxis is not administered routinely in Asian countries. Despite advances in the management of VTE, data in Asian populations on the incidence, prevalence, recurrence, risk factors, and management of bleeding complications are limited and there is need for increased awareness. To that end, this review summarizes the available data on the epidemiology, risk stratification, diagnosis, and treatment considerations in the management of VTE in Asia.
Source Title: THROMBOSIS JOURNAL
URI: https://scholarbank.nus.edu.sg/handle/10635/237844
ISSN: 14779560
14779560
DOI: 10.1186/s12959-017-0155-z
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