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https://doi.org/10.3390/cancers14071756
Title: | Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival | Authors: | Lim, Zi Lin Lim, Geok Hoon Ho, Peh Joo Khng, Alexis Jiaying Yeoh, Yen Shing Ong, Amanda Tse Woon Tan, Benita Kiat Tee Tan, Ern Yu Tan, Su-Ming Tan, Veronique Kiak-Mien Li, Jingmei Hartman, Mikael |
Keywords: | Science & Technology Life Sciences & Biomedicine Oncology breast cancer physical activity retrospective cohort study cancer survival RISK METAANALYSIS PREVENTION SUBTYPES THERAPY |
Issue Date: | 1-Apr-2022 | Publisher: | MDPI | Citation: | Lim, Zi Lin, Lim, Geok Hoon, Ho, Peh Joo, Khng, Alexis Jiaying, Yeoh, Yen Shing, Ong, Amanda Tse Woon, Tan, Benita Kiat Tee, Tan, Ern Yu, Tan, Su-Ming, Tan, Veronique Kiak-Mien, Li, Jingmei, Hartman, Mikael (2022-04-01). Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival. CANCERS 14 (7). ScholarBank@NUS Repository. https://doi.org/10.3390/cancers14071756 | Abstract: | Physical activity (PA) is known to reduce breast cancer (BC) risk and improve patient prognosis. However, the association between pre-diagnostic PA and the aggressiveness of BC is unclear. We investigated the associations between PA, BC tumour characteristics, and survival. This retrospective observational study included 7688 BC patients from the Singapore Breast Cancer Cohort (2010–2016). PA information from the questionnaire included intensity (light/moderate/vigorous) and duration (<1 h/1–2 h/>2 h per week). A PA score (1–5) incorporating intensity and duration was calculated. Associations between PA score and tumour characteristics such as stage, histo-logical grade, nodal and hormone receptor status were examined using multinomial regression. Moreover, 10-year overall survival was estimated using Cox regression analysis in 6572 patients after excluding patients with invalid survival data and stage IV disease. Breast tumours associated with higher PA score were more likely to be non-invasive (ORinvasive vs. non-invasive(reference) [95% CI]: 0.71 [0.58–0.87], p-trend = 0.001), of lower grade (ORpoorly vs. well differentiated(reference): 0.69 [0.52–0.93], p = 0.014), ER-positive (ORER-negative vs. ER-positive(reference): 0.94 [0.89–1.00], p-trend = 0.049), PR-positive (ORPR-negative vs. PR-positive(reference): 0.82 [0.67–0.99], p = 0.041), HER2-negative (ORHER2-negative vs. HER2-positive(reference): 1.29 [1.02–1.62], p-trend = 0.002), and less likely to be of HER2-overexpressed subtype (ORHER2-overexpressed vs. Luminal A(reference): 0.89 [0.81–0.98], p-trend = 0.018). These associations (odds ratios) were more pronounced among post-menopausal patients. A higher PA score did not improve survival. Higher levels of pre-diagnostic PA were associated with less aggressive tumours in BC patients. This illustrated another benefit of PA in addition to its known role in BC risk reduction. | Source Title: | CANCERS | URI: | https://scholarbank.nus.edu.sg/handle/10635/237408 | ISSN: | 2072-6694 | DOI: | 10.3390/cancers14071756 |
Appears in Collections: | Elements Staff Publications |
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