Please use this identifier to cite or link to this item: https://doi.org/10.3390/cells10123348
Title: Pre-Clinical and Clinical Applications of Small Interfering RNAs (siRNA) and Co-Delivery Systems for Pancreatic Cancer Therapy
Authors: Mirzaei, Sepideh
Gholami, Mohammad Hossein
Ang, Hui Li
Hashemi, Farid
Zarrabi, Ali
Zabolian, Amirhossein
Hushmandi, Kiavash
Delfi, Masoud
Khan, Haroon
Ashrafizadeh, Milad
Sethi, Gautam 
Kumar, Alan Prem 
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
pancreatic cancer
small interfering RNA (siRNA)
drug resistance
co-delivery
nanoparticles
MESOPOROUS SILICA NANOPARTICLES
GROWTH-FACTOR RECEPTOR
POLYMER HYBRID NANOPARTICLES
IRON-OXIDE NANOPARTICLES
RIG-I ACTIVATION
CELL LUNG-CANCER
HISTONE-DEACETYLASE
RIBONUCLEOTIDE REDUCTASE
GOLD NANOPARTICLES
DRUG-DELIVERY
Issue Date: 1-Dec-2021
Publisher: MDPI
Citation: Mirzaei, Sepideh, Gholami, Mohammad Hossein, Ang, Hui Li, Hashemi, Farid, Zarrabi, Ali, Zabolian, Amirhossein, Hushmandi, Kiavash, Delfi, Masoud, Khan, Haroon, Ashrafizadeh, Milad, Sethi, Gautam, Kumar, Alan Prem (2021-12-01). Pre-Clinical and Clinical Applications of Small Interfering RNAs (siRNA) and Co-Delivery Systems for Pancreatic Cancer Therapy. CELLS 10 (12). ScholarBank@NUS Repository. https://doi.org/10.3390/cells10123348
Abstract: Pancreatic cancer (PC) is one of the leading causes of death and is the fourth most malignant tumor in men. The epigenetic and genetic alterations appear to be responsible for development of PC. Small interfering RNA (siRNA) is a powerful genetic tool that can bind to its target and reduces expression level of a specific gene. The various critical genes involved in PC progression can be effectively targeted using diverse siRNAs. Moreover, siRNAs can enhance efficacy of chemotherapy and radiotherapy in inhibiting PC progression. However, siRNAs suffer from different off target effects and their degradation by enzymes in serum can diminish their potential in gene silencing. Loading siRNAs on nanoparticles can effectively protect them against degradation and can inhibit off target actions by facilitating targeted delivery. This leads to enhanced efficacy of siRNAs in PC therapy. Moreover, different kinds of nanoparticles such as polymeric nanoparticles, lipid nanoparticles and metal nanostructures have been applied for optimal delivery of siRNAs that are discussed in this article. This review also reveals that how naked siRNAs and their delivery systems can be exploited in treatment of PC and as siRNAs are currently being applied in clinical trials, significant progress can be made by translating the current findings into the clinical settings.
Source Title: CELLS
URI: https://scholarbank.nus.edu.sg/handle/10635/237216
ISSN: 2073-4409
DOI: 10.3390/cells10123348
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