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https://doi.org/10.3390/cells10123348
Title: | Pre-Clinical and Clinical Applications of Small Interfering RNAs (siRNA) and Co-Delivery Systems for Pancreatic Cancer Therapy | Authors: | Mirzaei, Sepideh Gholami, Mohammad Hossein Ang, Hui Li Hashemi, Farid Zarrabi, Ali Zabolian, Amirhossein Hushmandi, Kiavash Delfi, Masoud Khan, Haroon Ashrafizadeh, Milad Sethi, Gautam Kumar, Alan Prem |
Keywords: | Science & Technology Life Sciences & Biomedicine Cell Biology pancreatic cancer small interfering RNA (siRNA) drug resistance co-delivery nanoparticles MESOPOROUS SILICA NANOPARTICLES GROWTH-FACTOR RECEPTOR POLYMER HYBRID NANOPARTICLES IRON-OXIDE NANOPARTICLES RIG-I ACTIVATION CELL LUNG-CANCER HISTONE-DEACETYLASE RIBONUCLEOTIDE REDUCTASE GOLD NANOPARTICLES DRUG-DELIVERY |
Issue Date: | 1-Dec-2021 | Publisher: | MDPI | Citation: | Mirzaei, Sepideh, Gholami, Mohammad Hossein, Ang, Hui Li, Hashemi, Farid, Zarrabi, Ali, Zabolian, Amirhossein, Hushmandi, Kiavash, Delfi, Masoud, Khan, Haroon, Ashrafizadeh, Milad, Sethi, Gautam, Kumar, Alan Prem (2021-12-01). Pre-Clinical and Clinical Applications of Small Interfering RNAs (siRNA) and Co-Delivery Systems for Pancreatic Cancer Therapy. CELLS 10 (12). ScholarBank@NUS Repository. https://doi.org/10.3390/cells10123348 | Abstract: | Pancreatic cancer (PC) is one of the leading causes of death and is the fourth most malignant tumor in men. The epigenetic and genetic alterations appear to be responsible for development of PC. Small interfering RNA (siRNA) is a powerful genetic tool that can bind to its target and reduces expression level of a specific gene. The various critical genes involved in PC progression can be effectively targeted using diverse siRNAs. Moreover, siRNAs can enhance efficacy of chemotherapy and radiotherapy in inhibiting PC progression. However, siRNAs suffer from different off target effects and their degradation by enzymes in serum can diminish their potential in gene silencing. Loading siRNAs on nanoparticles can effectively protect them against degradation and can inhibit off target actions by facilitating targeted delivery. This leads to enhanced efficacy of siRNAs in PC therapy. Moreover, different kinds of nanoparticles such as polymeric nanoparticles, lipid nanoparticles and metal nanostructures have been applied for optimal delivery of siRNAs that are discussed in this article. This review also reveals that how naked siRNAs and their delivery systems can be exploited in treatment of PC and as siRNAs are currently being applied in clinical trials, significant progress can be made by translating the current findings into the clinical settings. | Source Title: | CELLS | URI: | https://scholarbank.nus.edu.sg/handle/10635/237216 | ISSN: | 2073-4409 | DOI: | 10.3390/cells10123348 |
Appears in Collections: | Staff Publications Elements |
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