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https://doi.org/10.3390/ph15050624
Title: | Targeting Nuclear Receptors in Lung Cancer-Novel Therapeutic Prospects | Authors: | Gangwar, Shailendra Kumar Kumar, Aviral Yap, Kenneth Chun-Hong Jose, Sandra Parama, Dey Sethi, Gautam Kumar, Alan Prem Kunnumakkara, Ajaikumar B |
Keywords: | Science & Technology Life Sciences & Biomedicine Chemistry, Medicinal Pharmacology & Pharmacy lung cancer nuclear receptors agonists/antagonists biomarker cell growth VITAMIN-D-RECEPTOR TRANS-RETINOIC ACID GROWTH-FACTOR RECEPTOR PREGNANE-X-RECEPTOR STEROID-HORMONE RECEPTORS PPAR-GAMMA LIGANDS PROLIFERATOR-ACTIVATED RECEPTORS ABERRANT PROMOTER METHYLATION BRONCHIAL EPITHELIAL-CELLS RXR-SELECTIVE RETINOIDS |
Issue Date: | 1-May-2022 | Publisher: | MDPI | Citation: | Gangwar, Shailendra Kumar, Kumar, Aviral, Yap, Kenneth Chun-Hong, Jose, Sandra, Parama, Dey, Sethi, Gautam, Kumar, Alan Prem, Kunnumakkara, Ajaikumar B (2022-05-01). Targeting Nuclear Receptors in Lung Cancer-Novel Therapeutic Prospects. PHARMACEUTICALS 15 (5). ScholarBank@NUS Repository. https://doi.org/10.3390/ph15050624 | Abstract: | Lung cancer, the second most commonly diagnosed cancer, is the major cause of fatalities worldwide for both men and women, with an estimated 2.2 million new incidences and 1.8 million deaths, according to GLOBOCON 2020. Although various risk factors for lung cancer pathogenesis have been reported, controlling smoking alone has a significant value as a preventive measure. In spite of decades of extensive research, mechanistic cues and targets need to be profoundly explored to develop potential diagnostics, treatments, and reliable therapies for this disease. Nuclear receptors (NRs) function as transcription factors that control diverse biological processes such as cell growth, differentiation, development, and metabolism. The aberrant expression of NRs has been involved in a variety of disorders, including cancer. Deregulation of distinct NRs in lung cancer has been associated with numerous events, including mutations, epigenetic modifications, and different signaling cascades. Substantial efforts have been made to develop several small molecules as agonists or antagonists directed to target specific NRs for inhibiting tumor cell growth, migration, and invasion and inducing apoptosis in lung cancer, which makes NRs promising candidates for reliable lung cancer therapeutics. The current work focuses on the importance of various NRs in the development and progression of lung cancer and highlights the different small molecules (e.g., agonist or antagonist) that influence NR expression, with the goal of establishing them as viable therapeutics to combat lung cancer. | Source Title: | PHARMACEUTICALS | URI: | https://scholarbank.nus.edu.sg/handle/10635/237210 | ISSN: | 1424-8247 | DOI: | 10.3390/ph15050624 |
Appears in Collections: | Staff Publications Elements |
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