Please use this identifier to cite or link to this item: https://doi.org/10.3390/biom13010057
Title: Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
Authors: Tuli, Hardeep Singh
Rath, Prangya
Chauhan, Abhishek
Ranjan, Anuj
Ramniwas, Seema
Sak, Katrin
Aggarwal, Diwakar
Kumar, Manoj
Dhama, Kuldeep
Lee, E Hui Clarissa 
Yap, Kenneth Chun-Yong
Capinpin, Sharah Mae 
Kumar, Alan Prem 
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
cucurbitacins
anti-proliferation
apoptotic
anti-angiogenic
anti-metastatic
synergism
OXYGEN SPECIES ROS
CELL LUNG-CANCER
ANTITUMOR-ACTIVITY
ANTICANCER ACTIVITY
SIGNALING PATHWAY
INDUCED APOPTOSIS
JAK2/STAT3
INHIBITION
GROWTH
PROLIFERATION
Issue Date: 1-Jan-2023
Publisher: MDPI
Citation: Tuli, Hardeep Singh, Rath, Prangya, Chauhan, Abhishek, Ranjan, Anuj, Ramniwas, Seema, Sak, Katrin, Aggarwal, Diwakar, Kumar, Manoj, Dhama, Kuldeep, Lee, E Hui Clarissa, Yap, Kenneth Chun-Yong, Capinpin, Sharah Mae, Kumar, Alan Prem (2023-01-01). Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends. BIOMOLECULES 13 (1). ScholarBank@NUS Repository. https://doi.org/10.3390/biom13010057
Abstract: Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested that inhibition of tumor cell growth via induction of apoptosis, cell-cycle arrest, anti-metastasis and anti-angiogenesis are major promising chemo-preventive actions of cucurbitacins. Cucurbitacins may be a potential choice for investigations of synergism with other drugs to reverse cancer cells’ treatment resistance. The detailed molecular mechanisms underlying these effects include interactions between cucurbitacins and numerous cellular targets (Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, VEGF/R, etc.) as well as control of a variety of intracellular signal transduction pathways. The current study is focused on the efforts undertaken to find possible molecular targets for cucurbitacins in suppressing diverse malignant processes. The review is distinctive since it presents all potential molecular targets of cucurbitacins in cancer on one common podium.
Source Title: BIOMOLECULES
URI: https://scholarbank.nus.edu.sg/handle/10635/237165
ISSN: 2218-273X
DOI: 10.3390/biom13010057
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