Please use this identifier to cite or link to this item: https://doi.org/10.3389/fneur.2021.791193
Title: One-Year Risk of Stroke After Transient Ischemic Attack or Minor Stroke in Hunter New England, Australia (INSIST Study)
Authors: Tomari, Shinya
Levi, Christopher R
Holliday, Elizabeth
Lasserson, Daniel
Valderas, Jose M 
Dewey, Helen M
Barber, P Alan
Spratt, Neil J
Cadilhac, Dominique A
Feigin, Valery L
Rothwell, Peter M
Zareie, Hossein
Garcia-Esperon, Carlos
Davey, Andrew
Najib, Nashwa
Sales, Milton
Magin, Parker
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
transient ischemic attack
minor stroke
stroke-mimic syndrome
one-year risk of ischemic stroke
community-based study
EARLY RECURRENT STROKE
URGENT TREATMENT
EXPRESS
MODEL
CARE
Issue Date: 20-Dec-2021
Publisher: FRONTIERS MEDIA SA
Citation: Tomari, Shinya, Levi, Christopher R, Holliday, Elizabeth, Lasserson, Daniel, Valderas, Jose M, Dewey, Helen M, Barber, P Alan, Spratt, Neil J, Cadilhac, Dominique A, Feigin, Valery L, Rothwell, Peter M, Zareie, Hossein, Garcia-Esperon, Carlos, Davey, Andrew, Najib, Nashwa, Sales, Milton, Magin, Parker (2021-12-20). One-Year Risk of Stroke After Transient Ischemic Attack or Minor Stroke in Hunter New England, Australia (INSIST Study). FRONTIERS IN NEUROLOGY 12 (4). ScholarBank@NUS Repository. https://doi.org/10.3389/fneur.2021.791193
Abstract: Background: One-year risk of stroke in transient ischemic attack and minor stroke (TIAMS) managed in secondary care settings has been reported as 5–8%. However, evidence for the outcomes of TIAMS in community care settings is limited. Methods: The INternational comparison of Systems of care and patient outcomes In minor Stroke and TIA (INSIST) study was a prospective inception cohort community-based study of patients of 16 general practices in the Hunter–Manning region (New South Wales, Australia). Possible-TIAMS patients were recruited from 2012 to 2016 and followed-up for 12 months post-index event. Adjudication as TIAMS or TIAMS-mimics was by an expert panel. We established 7-days, 90-days, and 1-year risk of stroke, TIA, myocardial infarction (MI), coronary or carotid revascularization procedure and death; and medications use at 24 h post-index event. Results: Of 613 participants (mean age; 70 ± 12 years), 298 (49%) were adjudicated as TIAMS. TIAMS-group participants had ischemic strokes at 7-days, 90-days, and 1-year, at Kaplan-Meier (KM) rates of 1% (95% confidence interval; 0.3, 3.1), 2.1% (0.9, 4.6), and 3.2% (1.7, 6.1), respectively, compared to 0.3, 0.3, and 0.6% of TIAMS-mimic-group participants. At one year, TIAMS-group-participants had twenty-five TIA events (KM rate: 8.8%), two MI events (0.6%), four coronary revascularizations (1.5%), eleven carotid revascularizations (3.9%), and three deaths (1.1%), compared to 1.6, 0.6, 1.0, 0.3, and 0.6% of TIAMS-mimic-group participants. Of 167 TIAMS-group participants who commenced or received enhanced therapies, 95 (57%) were treated within 24 h post-index event. For TIAMS-group participants who commenced or received enhanced therapies, time from symptom onset to treatment was median 9.5 h [IQR 1.8–89.9]. Conclusion: One-year risk of stroke in TIAMS participants was lower than reported in previous studies. Early implementation of antiplatelet/anticoagulant therapies may have contributed to the low stroke recurrence.
Source Title: FRONTIERS IN NEUROLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/236298
ISSN: 1664-2295
1836-7399
DOI: 10.3389/fneur.2021.791193
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