Please use this identifier to cite or link to this item: https://doi.org/10.1159/000513325
Title: Role of Upper Respiratory Microbiota and Virome in Childhood Rhinitis and Wheeze: Collegium Internationale Allergologicum Update 2021
Authors: Tay, Carina Jing Xuan 
Ta, Le Duc Huy 
Ow Yeong, Yu Xiang
Yap, Gaik Chin 
Chu, Justin Jang Hann 
Lee, Bee Wah 
Tham, Elizabeth Huiwen
Keywords: Science & Technology
Life Sciences & Biomedicine
Allergy
Immunology
Microbiota
Virome
Nasal microbiome
Wheeze
Rhinitis
Issue Date: 15-Feb-2021
Publisher: KARGER
Citation: Tay, Carina Jing Xuan, Ta, Le Duc Huy, Ow Yeong, Yu Xiang, Yap, Gaik Chin, Chu, Justin Jang Hann, Lee, Bee Wah, Tham, Elizabeth Huiwen (2021-02-15). Role of Upper Respiratory Microbiota and Virome in Childhood Rhinitis and Wheeze: Collegium Internationale Allergologicum Update 2021. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 182 (4) : 265-276. ScholarBank@NUS Repository. https://doi.org/10.1159/000513325
Abstract: There is emerging evidence that the respiratory microbiota influences airway health, and there has been intense research interest in its role in respiratory infections and allergic airway disorders. This review aims to summarize current knowledge of nasal microbiome and virome and their associations with childhood rhinitis and wheeze. The healthy infant nasal microbiome is dominated by Corynebacteriaceae and Staphylococcaceae. In contrast, infants who subsequently develop respiratory disorders are depleted of these microbes and are instead enriched with Proteobacteria spp. Although human rhinovirus and human respiratory syncytial virus are well-documented major viral pathogens that trigger rhinitis and wheezing disorders in infants, recent limited data indicate that bacteriophages may have a role in respiratory health. Future work investigating the interplay between commensal microbiota, virome, and host immunological responses is an important step toward understanding the dynamics of the nasal community in order to develop a strategical approach to combat these common childhood respiratory disorders.
Source Title: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/235433
ISSN: 1018-2438
1423-0097
DOI: 10.1159/000513325
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