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https://doi.org/10.4049/jimmunol.2200143
Title: | Comparison of Neutralizing Antibody Response Kinetics in Patients with Hand, Foot, and Mouth Disease Caused by Coxsackievirus A16 or Enterovirus A71: A Longitudinal Cohort Study of Chinese Children, 2017-2019 | Authors: | Zhou, Yonghong Zhou, Jiaxin Yang, Jianli Qiu, Qi Wang, Lili Yang, Junmei Li, Yu Liang, Lu Cui, Peng Cheng, Yibing Zheng, Wen Shi, Huilin Gong, Hui Wang, Kai Zhou, Chongchen Chu, Justin Jang Hann Yu, Hongjie |
Keywords: | Science & Technology Life Sciences & Biomedicine Immunology INFECTIONS |
Issue Date: | 15-Jul-2022 | Publisher: | AMER ASSOC IMMUNOLOGISTS | Citation: | Zhou, Yonghong, Zhou, Jiaxin, Yang, Jianli, Qiu, Qi, Wang, Lili, Yang, Junmei, Li, Yu, Liang, Lu, Cui, Peng, Cheng, Yibing, Zheng, Wen, Shi, Huilin, Gong, Hui, Wang, Kai, Zhou, Chongchen, Chu, Justin Jang Hann, Yu, Hongjie (2022-07-15). Comparison of Neutralizing Antibody Response Kinetics in Patients with Hand, Foot, and Mouth Disease Caused by Coxsackievirus A16 or Enterovirus A71: A Longitudinal Cohort Study of Chinese Children, 2017-2019. JOURNAL OF IMMUNOLOGY 209 (2) : 280-287. ScholarBank@NUS Repository. https://doi.org/10.4049/jimmunol.2200143 | Abstract: | Hand, foot, and mouth disease (HFMD), which is mainly caused by coxsackievirus A16 (CVA16) or enterovirus A71 (EV-A71), poses a serious threat to children's health. However, the long-term dynamics of the neutralizing Ab (NAb) response and ideal pairedserum sampling time for serological diagnosis of CVA16-infected HFMD patients were unclear. In this study, 336 CVA16 and 253 EV-A71 PCR-positive HFMD inpatients were enrolled and provided 452 and 495 sera, respectively, for NAb detection. Randomintercept modeling with B-spline was conducted to characterize NAb response kinetics. The NAb titer of CVA16 infection patients was estimated to increase from negative (2.1, 95% confidence interval [CI]: 1.4-3.3) on the day of onset to a peak of 304.8 (95% CI: 233.4-398.3) on day 21 and then remained >64 until 26 mo after onset. However, the NAb response level of EV-A71-infected HFMD patients was much higher than that of CVA16-infected HFMD patients throughout. The geometric mean titer was significantly higher in severe EV-A71-infected patients than in mild patients, with a 2.0-fold (95% CI: 1.4-3.2) increase. When a 4-fold rise in titer was used as the criterion for serological diagnosis of CVA16 and EV-A71 infection, acute-phase serum needs to be collected at 0-5 d, and the corresponding convalescent serum should be respectively collected at 17.4 (95% CI: 9.6-27.4) and 24.4 d (95% CI: 15.3-38.3) after onset, respectively. In conclusion, both CVA16 and EV-A71 infection induce a persistent humoral immune response but have different NAb response levels and paired-serum sampling times for serological diagnosis. Clinical severity can affect the anti-EV-A71 NAb response. | Source Title: | JOURNAL OF IMMUNOLOGY | URI: | https://scholarbank.nus.edu.sg/handle/10635/235418 | ISSN: | 0022-1767 1550-6606 |
DOI: | 10.4049/jimmunol.2200143 |
Appears in Collections: | Staff Publications Elements |
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