Please use this identifier to cite or link to this item:
https://doi.org/10.4049/jimmunol.2200143
DC Field | Value | |
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dc.title | Comparison of Neutralizing Antibody Response Kinetics in Patients with Hand, Foot, and Mouth Disease Caused by Coxsackievirus A16 or Enterovirus A71: A Longitudinal Cohort Study of Chinese Children, 2017-2019 | |
dc.contributor.author | Zhou, Yonghong | |
dc.contributor.author | Zhou, Jiaxin | |
dc.contributor.author | Yang, Jianli | |
dc.contributor.author | Qiu, Qi | |
dc.contributor.author | Wang, Lili | |
dc.contributor.author | Yang, Junmei | |
dc.contributor.author | Li, Yu | |
dc.contributor.author | Liang, Lu | |
dc.contributor.author | Cui, Peng | |
dc.contributor.author | Cheng, Yibing | |
dc.contributor.author | Zheng, Wen | |
dc.contributor.author | Shi, Huilin | |
dc.contributor.author | Gong, Hui | |
dc.contributor.author | Wang, Kai | |
dc.contributor.author | Zhou, Chongchen | |
dc.contributor.author | Chu, Justin Jang Hann | |
dc.contributor.author | Yu, Hongjie | |
dc.date.accessioned | 2022-12-08T07:01:33Z | |
dc.date.available | 2022-12-08T07:01:33Z | |
dc.date.issued | 2022-07-15 | |
dc.identifier.citation | Zhou, Yonghong, Zhou, Jiaxin, Yang, Jianli, Qiu, Qi, Wang, Lili, Yang, Junmei, Li, Yu, Liang, Lu, Cui, Peng, Cheng, Yibing, Zheng, Wen, Shi, Huilin, Gong, Hui, Wang, Kai, Zhou, Chongchen, Chu, Justin Jang Hann, Yu, Hongjie (2022-07-15). Comparison of Neutralizing Antibody Response Kinetics in Patients with Hand, Foot, and Mouth Disease Caused by Coxsackievirus A16 or Enterovirus A71: A Longitudinal Cohort Study of Chinese Children, 2017-2019. JOURNAL OF IMMUNOLOGY 209 (2) : 280-287. ScholarBank@NUS Repository. https://doi.org/10.4049/jimmunol.2200143 | |
dc.identifier.issn | 0022-1767 | |
dc.identifier.issn | 1550-6606 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/235418 | |
dc.description.abstract | Hand, foot, and mouth disease (HFMD), which is mainly caused by coxsackievirus A16 (CVA16) or enterovirus A71 (EV-A71), poses a serious threat to children's health. However, the long-term dynamics of the neutralizing Ab (NAb) response and ideal pairedserum sampling time for serological diagnosis of CVA16-infected HFMD patients were unclear. In this study, 336 CVA16 and 253 EV-A71 PCR-positive HFMD inpatients were enrolled and provided 452 and 495 sera, respectively, for NAb detection. Randomintercept modeling with B-spline was conducted to characterize NAb response kinetics. The NAb titer of CVA16 infection patients was estimated to increase from negative (2.1, 95% confidence interval [CI]: 1.4-3.3) on the day of onset to a peak of 304.8 (95% CI: 233.4-398.3) on day 21 and then remained >64 until 26 mo after onset. However, the NAb response level of EV-A71-infected HFMD patients was much higher than that of CVA16-infected HFMD patients throughout. The geometric mean titer was significantly higher in severe EV-A71-infected patients than in mild patients, with a 2.0-fold (95% CI: 1.4-3.2) increase. When a 4-fold rise in titer was used as the criterion for serological diagnosis of CVA16 and EV-A71 infection, acute-phase serum needs to be collected at 0-5 d, and the corresponding convalescent serum should be respectively collected at 17.4 (95% CI: 9.6-27.4) and 24.4 d (95% CI: 15.3-38.3) after onset, respectively. In conclusion, both CVA16 and EV-A71 infection induce a persistent humoral immune response but have different NAb response levels and paired-serum sampling times for serological diagnosis. Clinical severity can affect the anti-EV-A71 NAb response. | |
dc.language.iso | en | |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Immunology | |
dc.subject | INFECTIONS | |
dc.type | Article | |
dc.date.updated | 2022-12-08T05:24:08Z | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.description.doi | 10.4049/jimmunol.2200143 | |
dc.description.sourcetitle | JOURNAL OF IMMUNOLOGY | |
dc.description.volume | 209 | |
dc.description.issue | 2 | |
dc.description.page | 280-287 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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ji2200143.pdf | Published version | 1.22 MB | Adobe PDF | CLOSED | Published | |
R221208n02_Manuscript.pdf | 1.44 MB | Adobe PDF | OPEN | Pre-print | View/Download |
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