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https://doi.org/10.18632/aging.103674
Title: | Inactive bowel movement and stroke are associated with increased risks of mild cognitive impairment among community-living Singapore elderly | Authors: | Huang, Kai-Yong Tang, Xian-Yan Yang, Li Zhang, Zhi-Yong Ye, Kaisy Xinhong Shen, Qing-Feng Wang, Xiu Zhu, Xiang-Hua Huang, Xiao-Wei Lu, Guo-Dong Feng, Lei |
Keywords: | Science & Technology Life Sciences & Biomedicine Cell Biology Geriatrics & Gerontology mild cognitive impairment bowel movement fruit consumption dietary habits stroke HYPERTENSION DEMENTIA FREQUENCY VERAPAMIL ADULTS LIFE |
Issue Date: | 15-Sep-2020 | Publisher: | IMPACT JOURNALS LLC | Citation: | Huang, Kai-Yong, Tang, Xian-Yan, Yang, Li, Zhang, Zhi-Yong, Ye, Kaisy Xinhong, Shen, Qing-Feng, Wang, Xiu, Zhu, Xiang-Hua, Huang, Xiao-Wei, Lu, Guo-Dong, Feng, Lei (2020-09-15). Inactive bowel movement and stroke are associated with increased risks of mild cognitive impairment among community-living Singapore elderly. AGING-US 12 (17) : 17257-17270. ScholarBank@NUS Repository. https://doi.org/10.18632/aging.103674 | Abstract: | Mild cognitive impairment (MCI), as a preclinical phase of dementia, provides an invaluable time window for intervention. Besides several proposed modifiable risk factors, the associations of MCI with dietary habits and bowel movement are not well clarified. We thus conducted a cross-sectional study of community-living Singapore elderly and focused on the relationship of clinically diagnosed MCI with dietary habits and bowel movement frequencies. The multiple logistic regression results showed that frequent (≥4 days per week) fruit consumption (P = 0.004), active (≥4 days per week) bowel movement within 10 minutes (P = 0.027), and years of schooling were negatively associated with MCI occurrence. In contrast, medical comorbidities including hypertension, stroke, and cataract/glaucoma were found to be risk factors. Furthermore, a Bayesian network model of causal inference detected five hypothesized causal-association paths leading to MCI, namely bowel movement, stroke, years of schooling via fruit consumption, hypertension via stroke and hypertension via cataract/glaucoma. The combination of the two direct factors (inactive bowel movement and stroke) reached a maximum conditional probability of 60.00% for MCI occurrence. Taken together, this study was the first to link bowel movement with MCI occurrence. In addition, it suggested five modifiable hypothesized causal-association paths to MCI. | Source Title: | AGING-US | URI: | https://scholarbank.nus.edu.sg/handle/10635/235197 | ISSN: | 1945-4589 | DOI: | 10.18632/aging.103674 |
Appears in Collections: | Elements Staff Publications |
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