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Title: Preclinical Large Animal In-Vivo Experiments for Surgically Implanted Atrioventricular Valve: Reappraisal and Systematic Review.
Authors: Sazzad, Faizus 
Kr, Ramanathan 
Beverly, Chan Li Xuan
Kiat, Tan Ying
Ganesh, Geetha
Kofidis, Theo 
Keywords: Atrioventricular Valve
In vivo
Large animal
Mitral bioprosthesis
Issue Date: 17-Jun-2022
Publisher: Bentham Science Publishers Ltd.
Citation: Sazzad, Faizus, Kr, Ramanathan, Beverly, Chan Li Xuan, Kiat, Tan Ying, Ganesh, Geetha, Kofidis, Theo (2022-06-17). Preclinical Large Animal In-Vivo Experiments for Surgically Implanted Atrioventricular Valve: Reappraisal and Systematic Review.. Curr Cardiol Rev 18. ScholarBank@NUS Repository.
Abstract: BACKGROUND: The development of atrioventricular bioprosthesis has witnessed an increasing drive toward clinical translation over the last few decades. A significant challenge in the clinical translation of an atrioventricular bioprosthesis from bench to bedside is the appropriate choice of a large animal model to test the safety and effectiveness of the device. METHODS: We conducted a systematic review of preclinical in vivo studies that would enable us to synthesize a recommended framework. PRISMA (Preferred Reporting Items for Systematic Reviews and MetaAnalyses) guidelines were followed to identify and extract relevant articles. RESULTS: Sheep was the most common choice of animal, with nine out of the 12 included studies being conducted on sheep. There were acute and chronic studies based on our search criteria. An average of ~20 and 5 animals were used for chronic and acute studies. One out of three acute studies and eight out of nine chronic studies were on stented heart valve bioprosthesis. All analyses were conducted on the implantation of atrioventricular valves with trileaflet, except for one chronic study on unileaflet valves and one chronic and acute study on bileaflet valves. CONCLUSION: Understanding the variance in past preclinical study designs may increase the appropriate utilization of large animal models. This synthesized evidence provides a preclinical Invivo studies framework for future research with an atrioventricular bioprosthesis.
Source Title: Curr Cardiol Rev
ISSN: 1573-403X
DOI: 10.2174/1573403X18666220617115216
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