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Title: UXT plays dual opposing roles on SARM-induced apoptosis
Authors: Sethurathinam, Shalini 
Singh, Laishram Pradeepkumar
Panneerselvam, Porkodi 
Byrne, Bernadette
Ding, Jeak Ling 
Keywords: Ubiquitously expressed transcript (UXT)
Sterile alpha and HEAT armadillo motif-containing protein (SARM)
Infection-inflammation condition
Mitochondrial depolarization
Issue Date: 11-Oct-2013
Publisher: Wiley
Citation: Sethurathinam, Shalini, Singh, Laishram Pradeepkumar, Panneerselvam, Porkodi, Byrne, Bernadette, Ding, Jeak Ling (2013-10-11). UXT plays dual opposing roles on SARM-induced apoptosis. FEBS LETTERS 587 (20) : 3296-3302. ScholarBank@NUS Repository.
Abstract: Apoptosis is a vital defense mechanism for the clearance of infected cells. Ubiquitously expressed transcript (UXT), which exists in two isoforms (V1 and V2), interact with both apoptotic and cellular proteins. By yeast two-hybrid analysis, we found that UXT interacts with SARM (sterile α and HEAT armadillo motif-containing protein). Since SARM is a TLR adaptor which induces intrinsic apoptosis following immune activation, we were prompted to query whether UXT and SARM might co-regulate apoptosis. We found that the UXT isoforms elicit dual opposing regulatory effects on SARM-induced apoptosis; while UXT V1, co-expressed with SARM, caused a reduction in caspase 8 activity, UXT V2 strongly increased caspase 8 activity and enhanced SARM-induced apoptosis by activating the extrinsic pathway and depolarizing the mitochondria. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Source Title: FEBS LETTERS
ISSN: 0014-5793
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