Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/234911
Title: Natural Antibodies Bridge Innate and Adaptive Immunity
Authors: Panda, Saswati 
Ding, Jeak L 
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
LOW-DENSITY-LIPOPROTEIN
CYTIDINE DEAMINASE AID
MONOMERIC 7S IGM
B-CELLS
MARGINAL-ZONE
IMMUNOGLOBULIN-M
INFLUENZA-VIRUS
APOPTOTIC CELLS
B-1 CELLS
AFFINITY MATURATION
Issue Date: 1-Jan-2015
Publisher: AMER ASSOC IMMUNOLOGISTS
Citation: Panda, Saswati, Ding, Jeak L (2015-01-01). Natural Antibodies Bridge Innate and Adaptive Immunity. JOURNAL OF IMMUNOLOGY 194 (1) : 13-20. ScholarBank@NUS Repository.
Abstract: Natural Abs, belonging to isotypes IgM, IgG3, and IgA, were discovered nearly half a century ago. Despite knowledge about the role of the polyreactive natural IgM in pathogen elimination, B cell survival and homeostasis, inflammatory diseases, and autoimmunity, there is a lack of clarity about the physiological role of natural IgG and natural IgA because they appear incapable of recognizing Ags on their own and are perceived as nonreactive. However, recent research revealed exciting functions of natural IgG in innate immunity. Natural IgG:lectin collaboration swiftly and effectively kills invading pathogens. These advances prompt further examination of natural Abs in immune defense and homeostasis, with the potential for developing novel therapeutics. This review provides new insights into the interaction between natural Abs and lectins, with implications on how interactions between molecules of the innate and adaptive immune systems bridge these two arms of immunity.
Source Title: JOURNAL OF IMMUNOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/234911
ISSN: 0022-1767
1550-6606
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