Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsami.2c05679
Title: Gold Nanostar@Polyaniline Theranostic Agent with High Photothermal Conversion Efficiency for Photoacoustic Imaging-Guided Anticancer Phototherapy at a Low Dosage
Authors: Wang, Yuanzheng
Yang, Yuanjiao
Yang, Liu
Lin, Yihang
Tian, Ying
Ni, Qianqian 
Wang, Shouju
Ju, Huangxian
Guo, Jingxing
Lu, Guangming
Keywords: photothermal conversion efficiency
low dosage
theranostic
Photothermal therapy
photoacoustic imaging
Issue Date: 29-Jun-2022
Publisher: American Chemical Society (ACS)
Citation: Wang, Yuanzheng, Yang, Yuanjiao, Yang, Liu, Lin, Yihang, Tian, Ying, Ni, Qianqian, Wang, Shouju, Ju, Huangxian, Guo, Jingxing, Lu, Guangming (2022-06-29). Gold Nanostar@Polyaniline Theranostic Agent with High Photothermal Conversion Efficiency for Photoacoustic Imaging-Guided Anticancer Phototherapy at a Low Dosage. ACS Applied Materials & Interfaces 14 (25) : 28570-28580. ScholarBank@NUS Repository. https://doi.org/10.1021/acsami.2c05679
Abstract: Due to the strong and tunable photothermal effect, metallic nanoparticles are of enormous interest in light-activated biomedical applications, such as photoacoustic imaging (PAI) and photothermal therapy (PTT). However, the photothermal conversion efficiency (PCE) of existing metallic photothermal agents is still unsatisfactory. Herein, we develop an efficient photothermal theranostic agent based on a gold nanostar@polyaniline core−shell nanocomposite with high PCE for PAIguided PTT at a low dosage. After optimizing the relative composition of polyaniline (PANI) and gold nanostars (AuNSs), this nanocomposite eventually empowers an outstanding PCE of up to 78.6%, which is much better than AuNSs or PANI alone and most of the existing photothermal theranostic agents. Besides, the nanocomposite can act as a targeted probe for tumors by hyaluronic acid (HA) modification without compromising the photothermal performance. The obtained nanoprobes named AuNSPHs exhibit promising biocompatibility and great performance of PAI-guided PTT to treat triple-negative breast cancer both in vitro and in vivo. More importantly, a single injection of AuNSPHs significantly suppresses tumor growth with a low dosage of Au (0.095 mg/kg), which is attributed to the high PCE of AuNSPHs. Taking advantage of the exhilarating photothermal conversion ability, this theranostic agent can safely potentiate the antitumor therapeutic efficacy of laser-induced ablation and holds great potential for future medical applications.
Source Title: ACS Applied Materials & Interfaces
URI: https://scholarbank.nus.edu.sg/handle/10635/234895
ISBN: 1944-8252
ISSN: 1944-8244
DOI: 10.1021/acsami.2c05679
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Gold Nanostar Polyaniline Theranostic Agent with High Photothermal Conversion Efficiency for Photoacoustic Imaging-Guided Anticancer Phototherapy at a Low Dosage.pdf6.22 MBAdobe PDF

CLOSED

Published

SCOPUSTM   
Citations

5
checked on Feb 3, 2023

Page view(s)

23
checked on Feb 2, 2023

Download(s)

1
checked on Feb 2, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.