Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.expneurol.2016.01.019
Title: Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease
Authors: Garcia-Miralles, Marta 
Ooi, Jolene
Bardile, Costanza Ferrari
Tan, Liang Juin 
George, Maya
Drum, Chester L 
Lin, Rachel Yanping
Hayden, Michael R 
Pouladi, Mahmoud A 
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Huntington's disease
Monoamine oxidase
Monoamine oxidase inhibitors
Mouse model
Psychiatric features
Depression
Anxiety
Monoamines
HIPPOCAMPAL NEUROGENESIS
GENE CARRIERS
OXIDASE
DEPRESSION
DYSFUNCTION
BEHAVIOR
ANXIETY
LITHIUM
MICE
PATHOGENESIS
Issue Date: 1-Apr-2016
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation: Garcia-Miralles, Marta, Ooi, Jolene, Bardile, Costanza Ferrari, Tan, Liang Juin, George, Maya, Drum, Chester L, Lin, Rachel Yanping, Hayden, Michael R, Pouladi, Mahmoud A (2016-04-01). Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease. EXPERIMENTAL NEUROLOGY 278 : 4-Oct. ScholarBank@NUS Repository. https://doi.org/10.1016/j.expneurol.2016.01.019
Abstract: Abnormal monoamine oxidase A and B (MAO-A/B) activity and an imbalance in monoamine neurotransmitters have been suggested to underlie the pathobiology of depression, a major psychiatric symptom observed in patients with neurodegenerative diseases, such as Huntington disease (HD). Increased MAO-A/B activity has been observed in brain tissue from patients with HD and in human and rodent HD neural cells. Using the YAC128 mouse model of HD, we studied the effect of an irreversible MAO-A inhibitor, clorgyline, on the levels of select monoamine neurotransmitters associated with affective function. We observed a decrease in striatal levels of the MAO-A/B substrates, dopamine and norepinephrine, in YAC128 HD mice compared with wild-type mice, which was accompanied by increased anxiety- and depressive-like behaviour at five months of age. Treatment for 26 days with clorgyline restored dopamine, serotonin, and norepinephrine neurotransmitter levels in the striatum and reduced anxiety- and depressive-like behaviour in YAC128 HD mice. This study supports a potential therapeutic use for MAO-A inhibitors in the treatment of depression and anxiety in patients with HD.
Source Title: EXPERIMENTAL NEUROLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/234700
ISSN: 00144886
10902430
DOI: 10.1016/j.expneurol.2016.01.019
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