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Title: The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms
Authors: Khoury, Joseph D
Solary, Eric
Abla, Oussama
Akkari, Yassmine
Alaggio, Rita
Apperley, Jane F
Bejar, Rafael
Berti, Emilio
Busque, Lambert
Chan, John KC
Chen, Weina
Chen, Xueyan
Chng, Wee-Joo 
Choi, John K
Colmenero, Isabel
Coupland, Sarah E
Cross, Nicholas CP
De Jong, Daphne
Elghetany, M Tarek
Takahashi, Emiko
Emile, Jean-Francois
Ferry, Judith
Fogelstrand, Linda
Fontenay, Michaela
Germing, Ulrich
Gujral, Sumeet
Haferlach, Torsten
Harrison, Claire
Hodge, Jennelle C
Hu, Shimin
Jansen, Joop H
Kanagal-Shamanna, Rashmi
Kantarjian, Hagop M
Kratz, Christian P
Li, Xiao-Qiu
Lim, Megan S
Loeb, Keith
Loghavi, Sanam
Marcogliese, Andrea
Meshinchi, Soheil
Michaels, Phillip
Naresh, Kikkeri N
Natkunam, Yasodha
Nejati, Reza
Ott, German
Padron, Eric
Patel, Keyur P
Patkar, Nikhil
Picarsic, Jennifer
Platzbecker, Uwe
Roberts, Irene
Schuh, Anna
Sewell, William
Siebert, Reiner
Tembhare, Prashant
Tyner, Jeffrey
Verstovsek, Srdan
Wang, Wei
Wood, Brent
Xiao, Wenbin
Yeung, Cecilia
Hochhaus, Andreas
Keywords: Science & Technology
Life Sciences & Biomedicine
Issue Date: 22-Jun-2022
Citation: Khoury, Joseph D, Solary, Eric, Abla, Oussama, Akkari, Yassmine, Alaggio, Rita, Apperley, Jane F, Bejar, Rafael, Berti, Emilio, Busque, Lambert, Chan, John KC, Chen, Weina, Chen, Xueyan, Chng, Wee-Joo, Choi, John K, Colmenero, Isabel, Coupland, Sarah E, Cross, Nicholas CP, De Jong, Daphne, Elghetany, M Tarek, Takahashi, Emiko, Emile, Jean-Francois, Ferry, Judith, Fogelstrand, Linda, Fontenay, Michaela, Germing, Ulrich, Gujral, Sumeet, Haferlach, Torsten, Harrison, Claire, Hodge, Jennelle C, Hu, Shimin, Jansen, Joop H, Kanagal-Shamanna, Rashmi, Kantarjian, Hagop M, Kratz, Christian P, Li, Xiao-Qiu, Lim, Megan S, Loeb, Keith, Loghavi, Sanam, Marcogliese, Andrea, Meshinchi, Soheil, Michaels, Phillip, Naresh, Kikkeri N, Natkunam, Yasodha, Nejati, Reza, Ott, German, Padron, Eric, Patel, Keyur P, Patkar, Nikhil, Picarsic, Jennifer, Platzbecker, Uwe, Roberts, Irene, Schuh, Anna, Sewell, William, Siebert, Reiner, Tembhare, Prashant, Tyner, Jeffrey, Verstovsek, Srdan, Wang, Wei, Wood, Brent, Xiao, Wenbin, Yeung, Cecilia, Hochhaus, Andreas (2022-06-22). The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. LEUKEMIA 36 (7) : 1703-1719. ScholarBank@NUS Repository.
Abstract: The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.
Source Title: LEUKEMIA
ISSN: 0887-6924
DOI: 10.1038/s41375-022-01613-1
Appears in Collections:Staff Publications

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